Nausea and Vomiting Flashcards
Phenothiazines are __________ antagonists
Dopamine
True or false: prochlorperazine is less sedating than chlorpromazine
TRUE
When is haloperidol indicated as an anti-emetic
In palliative care
Which is antiemetic is preferred in Parkinson’s disease patients: metoclopramide or domperidone
Domperidone
It doesn’t cross the BBB
Ondansetron is an example of which class of anti-emetic
5HT3 receptor antagonists
What class of anti-emetic is aprepitant?
A neurokinin 1 receptor antagonist
True or false: a combination of two drugs with different mechanisms can be used in those at high risk of post-op N&V
TRUE
Drugs used include 5HT3-r antagonists, Dexamethasone, Prochlorperazine and Antihistamines
The most effective drug for preventing motion sickness is ________
Hyoscine hydrobromide (Kwells)
________ can be used for prevention of motion sickness if a sedative effect is required. It is slightly less sedating than cinnarizine and cyclizine
Promethazine
Metoclopramide should be used for a maximum of _____ days
5 days
MHRA 2013
True of false: metoclopramide cause hypotension
TRUE
This is listed as a common side effect in the BNF
True or false: Metoclopramide should be avoided in pregnancy
FALSE - it is not known to be harmful in pregnancy but should be avoided in breastfeeding as it can be present in milk
True or false: 5HT3 receptor antagonists such as ondansetron may cause QT prolongation and arrhythmias
TRUE - though this is listed as an uncommon side effect
True or false: ondansetron may be teratogenic, especially in the first trimester
TRUE
(MHRA 2020) Epidemiological studies have identified a small increased risk of cleft lip and/or palate
The disulfiram reaction with alcohol can cause:
3 points
Nausea and vomiting
Tachycardia
Severe headache
