Naturals and MIsc Flashcards
What is the mechanism for vincristine, and is there anything unique about it?
natural, vinca alkaloid, binds to beta-tubulin to cause metaphase arrest and apoptosis, prevents microtubule assembly.extravasational tand neurotoxicity
What is the mechanism for vinbalstine, and is there anything unique about it?
natural, vinca alkaloid. bind to beta-tubulin, prevent microtubule assembly, cause metaphase arrest and apoptosis.Extravastional toxicity and leukopenia
What is the mechanism for vinorelbine, and is there anything unique about it?
natural, vinca alkaloid, binds to beta-tubulin to prevent microbule assembly and metaphase. Apoptosis.extravasional toxicity, leukopenia
What is the mechanism for topotecan and irinotecan, and is there anything unique about it?
natural, camptothecin analog, stabalize DNA topoisomerase I cleavage complex, causing double DNA strand breaks. AchE inhibition, bad with Gilberts syndrome
What is the mechanism for etoposide and teniposide, and is there anything unique about it?
natural, podophyllotoxins, complex with topoisomerase II and DNAExtravasational toxicity. Resistance when p53 mutations are present
What is the mechanism for paclitaxel, and is there anything unique about it?
natural, taxane, bind to beta-tubulin to prevent microtubule DISsassembly.extravasational and “stocking-glove”
What is the mechanism for docetaxel, and is there anything unique about it?
natural, taxane, bind to beta-tubulin to prevent microtubule DISsassembly.extravasational and edema fluid retention
What is the mechanism for doxorubicin, daunorubicin, epirubicin, mitoxantrone, and is there anything unique about it?
natural, anthracyclines, intercalate with DNA, preveinging transcription and replication. Also complex with Topoisomerase II, generate free radicals from semiquinone.extravasational, CHF and LV dysfunction, cardiotoxicity.Give with Dexroxazone - iron chelator to reduce ccardiotoxicity.epirubicin -RED URINE from drug colorationmitoxantrone - bluegreen colored nails
What is the mechanism for bleomycin, and is there anything unique about it?
natural, bleomycin, drug-rion complex oxidizes deoxyribose of thymidylate and other nucleotides, causing sindle and double strand DNA breaks.extravasional and lung fibrosis.
What is the mechanism for actinomycin D, and is there anything unique about it?
natural, actinomycin, intercalate w DNA causing single DNA strand breaks via topoisomerase II inhibitionExtravasational, GI toxicity
What is the mechanism for asparaginase, and is there anything unique about it?
natural, asparaginase, converts asparagine to aspartic acid and ammonia, decreasing asparagine availability and inhibiting cell proliferation.Pacreatitis.
What is the mechanism for hydroxyurea, and is there anything unique about it?
scavenges free radicals required for conversion of ribonucleotides to deoxyribonucleotides.
What is the mechanism for thalidomide, and is there anything unique about it?
inhibits tumor cell proliferation, adhesion to stroma, angiongenesis, and enhances NK cell activity.Thromboembolic complications
What is the mechanism for tretinoin, and is there anything unique about it?
differentiating agent, disrupts the chimeric gene and promotes differentiation in acute promyelocytic leukemia
What is the mechanism for glucocorticoids and dexamthasone, and is there anything unique about it?
immunosuppressants that have anti-neoplastic effects
