Nasopharyngeal Flashcards
1
Q
Common viral etiology
A
EBV
5 year OS
Low pretreatment EBV copies & undetectable post RX: 87.2%
High pretreatment EBV copies & undetectable post RX: 71.0%
Detectable EBV copies post treatment: 38.7%
2
Q
RTOG 8817
Intergroup 00-99
A
Phase III trial , stage III/IV
RT vs CRT for Nasopharyngeal Ca
However, this study was not applicable to endemic regions
RT
70Gy
3 year PFS: 24%
3 year OS: 47%
CR: 36%
CRT
70Gy with cisplatin 100mg/m2 once a week for 3 weeks followed by
adjuvant chemo, (cisplatin 80mg/m2 on day 1) + (5-FU every 1-4 days) every 4 weeks x 3 cycles
3 year PFS: 69%
3 year OS: 78%
CR: 49%
