Narcotics: ADRs

Question 1

BUPRENORPHINE:

What are the MOST COMMON ADRs?

Answer 1

CNS:

• sedation
• dizziness

Neurologic:
-headache

CV:
-hypotension

Respiratory:
-respiratory depression

Dermatologic:
-application site rash (patch, implant)

GI:

• nausea
• vomiting
• constipation

Question 2

BUPRENORPHINE:

What are the RARE/SEVERE/IMPORTANT ADRs?

Answer 2

CV:
-QTc prolongation

Respiratory:
-respiratory depression

Hepatic:
-hepatotoxicity

Immunologic:
-severe allergic reactions

Question 3

FENTANYL:

What are the MOST COMMON ADRs?

Answer 3

CNS:

• sedation
• dizziness

GI:

• constipation
• nausea
• vomiting

Immunologic:

• pruritis (histamine release)
• skin rash (TD)

Other:
-xerostomia

Question 4

FENTANYL:

What are the RARE/SEVERE/IMPORTANT ADRs?

Answer 4

CNS:
-CNS depression

Psychiatric:
-hallucinations

CV:
-hypotension

Respiratory:
-respiratory depression

Question 5

HYDROCODONE:

What are the MOST COMMON ADRs?

Answer 5

GI:

• nausea
• vomiting
• constipation

Question 6

HYDROCODONE:

What are the RARE/SEVERE/IMPORTANT ADRs?

Answer 6

CV:
-QTc interval prolongation

Respiratory:
-respiratory depression