Nanomedicine

Question 1

What is doxil?

Answer 1

drug doxorubicin HCL encapsulated in PEGylated liposome

Question 2

What does PEG do?

Answer 2

increases blood circulation of liposomes

Question 3

What is Abraxane?

Answer 3

nanoparticle formulation of paclitaxel complexed with serum albumin

Question 4

What type of nanomedicine was the covid-19 vaccine?

Answer 4

Lipid nanoparticle-mRNA formulations

Question 5

What are most drug targets localized to?

Answer 5

Subcellular compartments

Question 6

What is nanoparticle cell entry regulated by?

Answer 6

admission by (receptor) invitation only shape & surface read at door

Question 7

What are 2 challenges in nanotherapeutics?

Answer 7

Immunological clearance in liver & spleen
Endo-lysomal entrapment of nanoparticles

Question 8

What does amorphous silica in human serum affect nanotherapeutics?

Answer 8

affects disperability & hard corona (slowly exchanging layer) at surface of particle

Question 9

What is found on amorphous silica?

Answer 9

APO B1

Question 10

What are 5 key particle parameters controlling recognition synapse?

Answer 10

Size,
shape,
rigidity,
ligand density,
surface charge

Question 11

What are 4 discovery frameworks for nanoscale shape-based adjuvants?

Answer 11

Quantitative definition of nanoscale shape
Programmable shape synthesis platform
Approach for searching biologically important shape regions
Pre-clinical models to test efficacy & safety

Question 12

How many different adjuvants are there?

Answer 12

12

Question 13

Define particle adjuvancy?

Answer 13

mechanistic understanding of bionanosynapse