Name these pictures Flashcards
Draw D- glucose and L-glucose
Describe what mutarotation is
The specific rotation of polarised light to equilibrium point
Draw a-D-glucopyranosyl-(1,4)-a-D-glucopyranose
Describe starch, found, types and linkages
Amylose (a-1,4)
Amylopectin (a-1,4 & a-1,6)
Found in plants to provide and store energy
Describe where glycogen is found, what’s it’s stored as and linkages
Liver and muscle tissues
a-1,4
Storage form of carbohydrates
Describe cellulose, where it’s found and linkages
Provides structure and fibre
Found in plants, wood
B-1,4
What does the HMG CoA redux taste inhibitor do to mevalonic acid?
What does it lead to?
What is meant by transition state inhibitor?
Drug works on enzyme to stop HMGCoA being produced in the first place
If a drug has lots of benzene rings it is hydrophobic?
Yes
Predict relative binding affinities of HMG CoA and atorvastatin for the HMG CoA reductase. Affinity is measured in Mm which compound would have the lower value?
Drug needs to bond more strongly otherwise it won’t inhibit
Preference over enzyme
Why do mevastatin and lovastatin have such high binding affinity for HMG CoA reductase?
When the ester is hydrolysed, they are structurally similar to the intermediate in the reduction of HMG CoA to mevalonic acid
More hydrophobic increased hydrophilicity leads to better selectivity and reduction in side effects
What happens in acid hydrolysis ?
OH onto main chain
+ NHCl into
What happens in basic hydrolysis?
Name these structures
Amines salt formation
Name and draw 7 amino acids
Describe
Primary
Secondary
Tertiary
Quarternary
Draw carboxylic acid
Draw a ketone
Draw an ester
Draw an aldehyde
Draw an amide
Draw an alcohol