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Step 1 Marielle FIRST AID NOTES > Name that Oncogene or Tumor Suppressor? > Flashcards

Name that Oncogene or Tumor Suppressor? Flashcards

1
Q

BCR-ABL

A

Oncogene
TK
ALL/CML

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2
Q

BCL-2

A

Oncogene
Antiapototic molecule
Follicular and undifferentiated lymphoma

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3
Q

BRAF

A

Oncogene
Serine/threonine kinase
melanoma and NHL

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4
Q

c-kit

A

Oncogene
Cytokine receptor
Gastrointestinal stromal tumor (GIST)

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5
Q

c-myc

A

Oncogene
Transcription factor
Burkitt lymphoma

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6
Q

HER2/Neu (c-erbB2)

A

Oncogene
TK
Breast, Ovarian, and gastric carcinomas

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7
Q

L-myc

A

Oncogene
Transcription fx
Lung tumor

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8
Q

N-myc

A

Oncogene
transcription fx
Neuroblastoma

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9
Q

RAS

A

Oncogene
GTPase
Colon cancer, lung cancer, pancreatic cancer

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10
Q

RET

A

Oncogene
TK
MEN2A/B, medullary thyroid cancer

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11
Q

APC

A 
Tumor Suppressor
Colorectal cancer (FAP)
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12
Q

BRCA1/BRCA2

A

Tumor Suppressor
DNA repair protein
Breast and Ovarian Cancer

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13
Q

DCC

A

Tumor Suppressor
DCC (deleted in colon cancer)
colon cancer

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14
Q

DPC4/SMAD4

A

Tumor Suppressor
DPC (deleted in panc cancer)
Pancreatic cancer

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15
Q

MEN1

A

Tumor Suppressor
Menin
MEN1

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16
Q

NF1

A

Tumor Suppressor
RAS GTP-ase activating protein (neurofibromin)
NF1

17
Q

NF2

A

Tumor Suppressor
Merlin (schwannomin) protein
NF2

18
Q

p16

A

Tumor Suppressor
Cyclin-dependent Kinase inhibitor 2A
Melanoma

19
Q

p53

A

Tumor suppressor
transcription fx for p21, blocks G2–> S phase
most human cancers, Li-Fraumeni

20
Q

PTEN

A

Tumor Suppressor

breast, prostate, endometrial cancer

21
Q

Rb

A

Tumor Suppressor
Inhibits E2F, blocks G1–> S phase
Retinoblastoma, osteosarcoma

22
Q

TSC1

A

Tumor Suppressor
Harmartin Protein
Tuberous sclerosis

23
Q

TSC2

A

Tumor Suppressor
Tuberin protein
Tuberous sclerosis

24
Q

VHL

A

Tumor Suppressor
Inhibits hypoxia inducible factor 1a
VHL disease, RCC

25
Q

WT1/WT2

A 
Tumor Suppressor
Wilms tumor (nephroblastoma)

Step 1 Marielle FIRST AID NOTES (3 decks)

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