name, mechanism of action and indication Flashcards
Ketorolac (Tordol)
Drug Class: Nonsteroidal anti-inflammatory drug (NSAID)
Mechanism of Action: Inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis and providing anti-inflammatory, analgesic, and antipyretic effects.
Indications: Short-term management of moderate to severe pain.
Acetaminophen (Tylenol)
- Indications: Fever
- NSAID
Morphine Sulfate (Morphine)
- Narcotic Analgesic
- CNS depressant and analgesic
- Indications: severe pain
Hydromorphone (Dilaudid)
- Narcotic analgesic that has longer lasting effects when compared to morphine
- Hemodynamic properties – increases the peripheral venous capacitance and decreases venous return and myocardial oxygen demand
- Indications: severe pain
Meperidine (Demerol)
- Narcotic analgesic that has shorter lasting effects when compared to morphine, can create dysphoria and can cause liver damage
- Schedule II controlled substance
- Indications: severe pain
Fentanyl Citrate (Sublimaze)
- Narcotic Analgesic
- Unrelated to morphine but 50-100 times more potent. Duration of action is shorter than other narcotics
- Indications: Pain, RSI Intubation
Diazepam (Valium)
- Indications: Major motor seizures, status epilepticus, premedication before cardioversion, skeletal muscle relaxant, and acute anxiety states.
Lorazepam (Ativan)
- Indications: Major motor seizures, status epilepticus, premedication before cardioversion, skeletal muscle relaxant, and acute anxiety states.
Midazolam (Versed)
- Indications: anticonvulsant.
Glucagon
Drug Class: Hyperglycemic agent
Mechanism of Action: Stimulates hepatic production of glucose from glycogen stores (glycogenolysis).
Indications: Severe hypoglycemia, beta-blocker overdose.
Dextrose (D50, D25, D10
- Indications: Hypoglycemia and coma of unknown origin.
Naloxone (Narcan)
- Indications: respiratory depression with a high index of suspicion of a narcotic overdose
Duo Dote Auto-injector
- Indications: Organophosphate or Nerve Agent Poisoning
Diphenhydramine (Benadryl)
- : Allergic reactions and anaphylaxis (secondary treatment)
Aspirin
- Indications: Chest Pain that is likely cardiac-related
Tranexamic Acid (TXA)
Drug Class: Antifibrinolytic
Mechanism of Action: Inhibits the activation of plasminogen to plasmin, preventing the breakdown of fibrin clots.
Indications: Control of bleeding in hemophilia, reduction of heavy menstrual bleeding, trauma-associated hemorrhage, surgical bleeding.
Nitroglycerin
- Indications: Chest pain associated with ACS or acute pulmonary edema
Epinephrine (Injectable)
- Indications: hypotension, primary treatment for allergic reactions/anaphylaxis, cardiac arrest, severe asthma, persistent and symptomatic bradycardia
Methylprednisolone (Solu-Medrol)
- Indications: second/tertiary treatment for severe anaphylaxis, asthma, COPD and urticaria
Albuterol
- Indications: Bronchial asthma and reversible bronchospasm associated with chronic bronchitis and emphysema.
Dexamethasone (Decadron)
Drug Class: Corticosteroid
Mechanism of Action: Suppresses inflammation and immune responses; has potent glucocorticoid effects.
Indications: Severe allergic reactions, asthma, croup, cerebral edema, inflammation.
Racemic Epinephrine
Drug Class: Sympathomimetic, bronchodilator
Mechanism of Action: Stimulates alpha and beta-adrenergic receptors, reducing airway
resistance and edema.
indications: Croup, bronchospasm.
Ipratropium (Atrovent)
Drug Class: Anticholinergic
Mechanism of Action: Inhibits the action of acetylcholine at muscarinic receptors in bronchial smooth muscle, causing bronchodilation.
Indications: Maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema; asthma exacerbations.
Ondansetron (Zofran)
- Indications: Nausea/Vomiting
Phenytoin ( Dilantin)
Drug Class: Anticonvulsant
Mechanism of Action: Stabilizes neuronal membranes and decreases seizure activity by increasing efflux or decreasing influx of sodium ions across cell membranes.
Indications: Seizure disorders, status epilepticus.
Fosphenytoin( Cerebyx)
Drug Class: Anticonvulsant
Mechanism of Action: Prodrug of phenytoin, converted to phenytoin in the body.
Indications: Status epilepticus, seizure prevention during neurosurgery.
Phenobarbital (Luminal)
Drug Class: Barbiturate
Mechanism of Action: Enhances the effect of GABA by increasing the duration of chloride channel opening.
Indications: Seizure disorders, status epilepticus, sedation.
Insulin (Humulin, Novolin)
Drug Class: Antidiabetic agent
Mechanism of Action: Lowers blood glucose by stimulating glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production.
Indications: Diabetes mellitus (Type 1 and Type 2), hyperkalemia (adjunct), diabetic ketoacidosis (DKA).
Dextrose (D50, D25, D10)
Drug Class: Carbohydrate
Mechanism of Action: Rapidly increases serum glucose levels.
Indications: Hypoglycemia.
Thiamine
Drug Class: Vitamin
Mechanism of Action: Essential coenzyme in carbohydrate metabolism.
Indications: Thiamine deficiency, Wernicke’s encephalopathy.
. Hydrocortisone (Solu-Cortef)
Drug Class: Corticosteroid
Mechanism of Action: Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.
Indications: Adrenal insufficiency, severe allergic reactions, asthma, septic shock
Nitrous Oxide
Drug Class: Anesthetic gas
Mechanism of Action: Produces analgesia and sedation by depressing the central nervous system.
Indications: Pain management, procedural sedation.
Ketamine
- Drug Class: Dissociative anesthetic
- Mechanism of Action: Blocks NMDA receptors, providing anesthesia and analgesia while preserving airway reflexes and spontaneous breathing.
- Indications: Induction and maintenance of anesthesia, procedural sedation, pain management, status asthmaticus.
Etomidate
Drug Class: General anesthetic
Mechanism of Action: Enhances GABA receptor activity, inducing sedation and anesthesia.
Indications: Induction of general anesthesia, procedural sedation
Propofol
Drug Class: General anesthetic
Mechanism of Action: Positive modulation of the inhibitory function of the neurotransmitter GABA through GABAA receptors.
Indications: Induction and maintenance of anesthesia, procedural sedation, sedation for mechanically ventilated patients.
Dexmedetomidine
Drug Class: Alpha-2 adrenergic agonist
Mechanism of Action: Activates alpha-2 adrenergic receptors in the brainstem, inhibiting the release of norepinephrine and providing sedation, analgesia, and anxiolysis.
Indications: Sedation of initially intubated and mechanically ventilated patients, procedural sedation.
Terbutaline
Drug Class: Beta-2 adrenergic agonist
Mechanism of Action: Stimulates beta-2 adrenergic receptors, causing bronchodilation and relaxation of uterine smooth muscle.
Indications: Bronchospasm in asthma and COPD, preterm labor.
Nebulized Atropine
Drug Class: Anticholinergic
Mechanism of Action: Inhibits the action of acetylcholine at parasympathetic sites in bronchial smooth muscle, causing bronchodilation.
Indications: Reversal of bronchospasm in asthma or COPD.
Magnesium Sulfate
Drug Class: Electrolyte, anticonvulsant
Mechanism of Action: Reduces muscle contractions by interfering with the release of acetylcholine at the neuromuscular junction; stabilizes cardiac cells.
Indications: Torsades de pointes, eclampsia, severe asthma exacerbations, hypomagnesemia.
Norepinephrine
Drug Class: Sympathomimetic, vasopressor
Mechanism of Action: Stimulates alpha and beta-1 adrenergic receptors, causing vasoconstriction and increased cardiac output.
Indications: Acute hypotensive states, cardiac arrest.
Dopamine
Drug Class: Sympathomimetic, vasopressor, inotrope
Mechanism of Action: Stimulates dopaminergic, beta-1, and alpha adrenergic receptors, increasing cardiac output and blood pressure.
Indications: Shock, congestive heart failure, hypotension not resulting from hypovolemia.
Dobutamine
Drug Class: Sympathomimetic, inotrope
Mechanism of Action: Stimulates beta-1 adrenergic receptors, increasing cardiac output without significantly increasing heart rate.
Indications: Acute heart failure, cardiogenic shock.
Vasopressin
Drug Class: Antidiuretic hormone, vasopressor
Mechanism of Action: Stimulates V1 receptors in vascular smooth muscle, causing vasoconstriction.
Indications: Diabetes insipidus, vasodilatory shock.
Propranolol
Drug Class: Beta-blocker (non-selective)
Mechanism of Action: Blocks beta-1 and beta-2 adrenergic receptors, reducing heart rate, myocardial contractility, and blood pressure.
Indications: Hypertension, angina, arrhythmias, migraine prophylaxis, tremors.
Metoprolol
Drug Class: Beta-blocker (beta-1 selective)
Mechanism of Action: Selectively blocks beta-1 adrenergic receptors, reducing heart rate, myocardial contractility, and blood pressure.
Indications: Hypertension, angina, acute myocardial infarction, heart failure, tachyarrhythmias.
Lidocaine
Drug Class: Antiarrhythmic (class 1B), local anesthetic
Mechanism of Action: Suppresses automaticity and spontaneous depolarization of the ventricles during diastole by altering sodium ion flux across cell membranes. Indications: Ventricular arrhythmias, local anesthesia.
Procainamide
Drug Class: Antiarrhythmic (class 1A)
Mechanism of Action: Blocks sodium channels, reducing automaticity and prolonging the refractory period of the atria, ventricles, and Purkinje fibers.
Indications: Ventricular arrhythmias, atrial fibrillation with rapid ventricular rate in WPW syndrome.
Verapamil
Drug Class: Calcium channel blocker
Mechanism of Action: Inhibits calcium ion influx into vascular smooth muscle and myocardium, decreasing myocardial contractility and oxygen demand, and dilating coronary arteries.
Indications: PSVT, atrial fibrillation/flutter with rapid ventricular rate, hypertension, angina.
Adenosine
Drug Class: Antiarrhythmic
Mechanism of Action: Slows conduction through the AV node and can interrupt reentrant pathways, restoring normal sinus rhythm.
Indications: Paroxysmal supraventricular tachycardia (PSVT).
Diltiazem
Drug Class: Calcium channel blocker
Mechanism of Action: Inhibits calcium ion influx into vascular smooth muscle and myocardium, decreasing myocardial contractility and oxygen demand, and dilating coronary arteries.
Indications: PSVT, atrial fibrillation/flutter with rapid ventricular rate, hypertension, angina.
Amiodarone
Drug Class: Antiarrhythmic (class III)
Mechanism of Action: Prolongs the action potential and refractory period of cardiac cells; inhibits adrenergic stimulation; decreases AV conduction and sinus node function.
Indications: Ventricular fibrillation, ventricular tachycardia, atrial fibrillation.
Atropine
Drug Class: Anticholinergic, parasympatholytic
Mechanism of Action: Inhibits the action of acetylcholine at parasympathetic sites in smooth muscle, CNS, and secretory glands, increasing heart rate and decreasing secretions.
Indications: Bradycardia, organophosphate poisoning, asystole.
Sodium Bicarbonate
Drug Class: Alkalinizing agent
Mechanism of Action: Increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH.
Indications: Metabolic acidosis, hyperkalemia, drug intoxications (e.g., tricyclic antidepressants), cardiac arrest with suspected hyperkalemia or acidosis.
Furosemide
Drug Class: Loop diuretic
Mechanism of Action: Inhibits reabsorption of sodium and chloride in the ascending loop of Henle, leading to increased excretion of water, sodium, chloride, magnesium, calcium, and potassium.
Indications: Edema associated with heart
Bumetanide
Drug Class: Loop diuretic
Mechanism of Action: Inhibits reabsorption of sodium and chloride in the ascending loop of Henle, leading to increased excretion of water, sodium, chloride, magnesium, and calcium.
Indications: Edema associated with heart failure, liver disease, or renal disease.
Captopril
Drug Class: Angiotensin-Converting Enzyme (ACE) Inhibitor
Mechanism of Action: Inhibits the conversion of angiotensin I to angiotensin II, leading to vasodilation, decreased aldosterone secretion, and reduced blood pressure.
Indications: Hypertension, heart failure, diabetic nephropathy, post-myocardial infarction.
Nicardipine
Drug Class: Calcium channel blocker
Mechanism of Action: Inhibits calcium ion influx into vascular smooth muscle and myocardium, causing vasodilation and decreased blood pressure.
Indications: Hypertensive emergencies, chronic stable angina, hypertension.
Sodium Nitroprusside
Drug Class: Vasodilator
Mechanism of Action: Releases nitric oxide, leading to vasodilation of both arteries and veins, reducing preload and afterload, and decreasing blood pressure.
Indications: Hypertensive emergencies, acute heart failure, controlled hypotension during surgery.
Calcium Chloride
Drug Class: Electrolyte supplement
Mechanism of Action: Increases the levels of extracellular calcium, crucial for cardiac and neuromuscular function.
Indications: Hypocalcemia, hyperkalemia, hypermagnesemia, calcium channel blocker overdose.
Succinylcholine
Drug Class: Neuromuscular blocking agent (depolarizing)
Mechanism of Action: Mimics acetylcholine at the neuromuscular junction, causing depolarization and subsequent paralysis by preventing repolarization.
Indications: Rapid sequence intubation (RSI), muscle relaxation during surgery or mechanical ventilation.
Pancuronium Bromide
Drug Class: Neuromuscular blocking agent (non-depolarizing)
Mechanism of Action: Blocks acetylcholine from binding to its receptors on muscles, preventing depolarization and causing paralysis.
Indications: Muscle relaxation during surgery or mechanical ventilation.
Vecuronium
Drug Class: Neuromuscular blocking agent (non-depolarizing)
Mechanism of Action: Blocks acetylcholine from binding to its receptors on muscles, preventing depolarization and causing paralysis.
Indications: Muscle relaxation during surgery or mechanical ventilation, rapid sequence intubation.
Rocuronium Bromide
Drug Class: Neuromuscular blocking agent (non-depolarizing)
Mechanism of Action: Blocks acetylcholine from binding to its receptors on muscles, preventing depolarization and causing paralysis.
Indications: Muscle relaxation during surgery or mechanical ventilation, rapid sequence intubation.