Naloxone

Question 1

Narcan

Class

Answer 1

• Narcotic antagonist

Question 2

Narcan

MOA

Answer 2

• Competitive inhibition at narcotic receptor sites
• Reverse respiratory depression secondary to opiate drugs
• Completely inhibits the effect of morphine

Question 3

Narcan

Indications

Answer 3

• Opiate OD
• Coma
• Complete or partial reversal of CNS and respiratory depression induced by opiods
• Decreased LOC of unknown origin
• Narcotic agonist for the following: morphine, heroin, Dilaudid, etc.

Question 4

Narcan

Contraindications

Answer 4

• Use with caution in narcotic-dependent pt’s
• Use with caution in neonates of narcotic-addicted mothers

Question 5

Narcan

Adverse reactions

Answer 5

• Withdrawal symptoms in the addicted pt
• Tachycardia
• HTN
• Arrhythmias
• N/V
• Diaphoresis

Question 6

Narcan

Drug interactions

Answer 6

• Incompatible with bisulfite and alkaline solutions

Question 7

Narcan

Dosage

Answer 7

Adult:

• 0.4 - 2.0 mg IV, IM, SC
  
  • Min recommended dose 0.4 mg
  • Repeat at 5 min intervals to max of 10 mg
• Infusion: 2 mg in 500 mL of D5W
  
  • infuse at 0.4 mg/hr (100 mL/h)

Ped:

• 0.1 mg/kg, Max of 0.8 mg, if no response in 10 min give another 0.1 mg/kg

Question 8

Narcan

Duration of action

Answer 8

• Onset: within 2 min
• Peak: varies
• Duration: 30-60 min

Question 9

Narcan

Special considerations

Answer 9

• Preg Cat: B
• SZ without causal relationship have been reported
• May not reverse hypotension
• Use caution when administering to narcotic addicts (potential for violent behavior)