Naloxone

Question 1

Receptors

Naloxone

Answer 1

Nonselective for Mu; ∆ (Delta); K (Kappa)

Pure antagonist; NO agonist activity

Question 2

E 1/2 Time

Naloxone

Answer 2

60 - 90 mins

Question 3

Duration:

Naloxone

Answer 3

30 - 45 mins

Question 4

Metabolism

Naloxone

Answer 4

Hepatic: Glucuronic acid conjugation

Question 5

Potency

Naloxone

Answer 5

High affinfity for opioid receptors; displaces opioids effectively

Question 6

Indications (Use)

Naloxone

Answer 6

opioid-induced depression in post op neonate* (from mom)
opioid overdose
detect dependence
Hypovolemic/septic shock-Increased myocardial contractility
Antagonism of general anesthesia (high doses)**

Question 7

CV Effects

Naloxone

Answer 7

Can cause cardiac dysrhythmias ([v-fib)

Question 8

Respiratory Effects

Naloxone

Answer 8

Reversal of respiratory depression

Question 9

Side Effects

Naloxone

Answer 9

Positive inotropic effect

reversal of analgesia*; N/V**; increased SNS (HR; BP; pulmonary edema;

Question 10

Naloxone normal dose

Naloxone

Answer 10

IV: 1-4 mcg/kg

Question 11

Naloxone continuous infusion

Naloxone

Answer 11

5 mcg/kg IV

Question 12

Naloxone Shock dose

Naloxone

Answer 12

> 1 mg/kg IV

Question 13

Naloxone Epidural dose

Naloxone

Answer 13

0.25 mcg/kg/hr