NAFLD Flashcards
0
Q
What LFTs for NAFLD?
A
Not required to diagnose
TRICK QUESTION
1
Q
NAFLD spectrum includes?
A
Steatosis (accumulation of fatty lipids)
Non-alcoholic steatohepatitis (steatosis plus ballooning degeneration of hepatocytes)
Cirrhosis
2
Q
What is the Pathogenesis of NAFLD due to?
A
Insulin resistance
Increased free fatty acids
Increased hepatic lipogenesis
3
Q
What type of patients have NAFLD?
A
80% DM
90% MORBIDLY OBESE
4
Q
Risk factors NAFLD?
A
Obesity
DM
Metabolic syndrome
Dyslipidaemia
5
Q
S + S?
A
ASYMPTOMATIC incidental change in LFTs
Rarely: RUQ pain, fatigue
6
Q
Ix?
A
CBE EUC LFTs
US liver is easy but will not gauge severity
Therefore liver biopsy required
7
Q
Management of NAFLD?
A
Non-pharmacological
- diet restriction and improvement
- regular exercise
- MUlti-D approach
Pharm
- statins
- vit E
- bariatric surgery to lose weight after portal HTN ruled out
Tx other RFs for CVS disease
