N/V/D Constipation IBS Flashcards
What NT are in the chemo receptor trigger zone?
5-HT
Dopamine
Muscarinic
What can nausea and vomiting lead to?
Dehydration
What should people who are N/V avoid?
Dairy (exception is a baby drinking breast milk/ formula)
What is the BRAT diet? (after 24 hour fluid diet)
Banana
Rice
Apple Sauce
Toast (dry)
What are 4 pharm treatment to stop N/V?
5-HT3 Antagonists
Dopamine Antagonists
Antihistamines
Cannabinoids
What are three 5-HT2 antagonists?
Ondansetron (Zofran)
Granisetron (Kytril)
Dolasetron (Anzemet)
ROA- oral, rectal, IM, IV
What is the 5-HT antagonist MOA?
Antagonism of the 5-HT3 receptor in the chemo-receptor trigger zone (CTZ)
Indications for 5-HT3 antagonists
Treatment and prevention of postoperative N/V (FDA)
Chemotherapy-induced N/V (FDA)
also given in ER a lot for N/V
ADRs of 5-HT3 antagonists
HA
Dizziness
Diarrhea
Abdominal pain
What are three dopamine antagonists
Metoclopramide (reglan)
Trimethobenzamide (Tigan)
Phenothiazines- Prochlorperazine (Compazine)
Promethazine
MOA of dopamine antagonists
Antagonist of D2 receptors in the CTZ
What dopamine antagonist at higher doses also blocks 5-HT3 receptors. Also promote gastric emptying and small intestine peristalsis—prokinetic effects
metoclopramide
Contraindications of dopamine antagonist
GI hemorrhage, obstruction or perf
Caution in patients w/ depression, seizures, children
ADRs of dopamine antagonist
Extrapyramidal effects (Parkinsonism) Restlessness, anxiety, drowsiness, fatigue, halluc.
CV- HPN, HPOTN, AV block, bradycardia, agranulocytosis
What antihistamine is used for N/V?
Promethazine
MOA of promethazine
Block H1 –> effectiveness appear to be with motion sickness and vestibulochochlear disease
Antagonist of D2 receptors in the CTZ
ADRs of promethazine
Parkinsonian symptoms (dyskinesia, dystonias, akathisia) Neuroleptic malignant syndrome
Who should you be cautious with for usage of promethazine
BPH
Urinary retention
glaucoma
Used is a tablet of cannabinoids?
Dronabinol
ADRs of dronabinol
Drowsiness
sedation
increased appetite
Best option for chemo therapy induced N/V
5-HT3 antagonist
Regulation of normal intestinal motility is under what control?
Neuronal
Hormonal
5 classes of drugs for GI motility
Laxatives Antidiarrheal agents Prokinetic agents Antiemetic agents Antispasmodics
Medical definition of constipation
Straining > 25% of time
Lumpy or hard stools > 25% of time
Feeling of incomplete evacuation > 25% of time
2 or fewer BM in 1 week
Medication causes for constipation
Opiates Ca and Al antacids Iron Calcium channel blockers Clonidine Anticholinergics
Best ways to control constipation
Drink plenty of water and fluids (P juices)
High fiber diet (whole grains, bran, fresh fruit and veggies)
what do laxatives do?
hasten transit time in the gut and encourage defecation
Used prior to medical procedure to clear bowel out
5 types of laxatives
Bulk-Forming Laxatives Emollients and Lubricants Saline Cathartics Osmotic Laxatives Stimulant Laxatives
Name the bulk forming laxatives
Psyllium (metamucil)
Methylcellulose (Citrucel)
Polycarbophil (Fibercon)
MOA of bulk forming laxatives
Increase volume of non-absorbable solid residue in water, stimulates peristalsis and increase rate of colonic transit
What is the first line therapy for bedridden or geriatric with chronic constipation. Good in pregnancy.
Bulk-forming laxatives
Contraindications of bulk-forming laxatives
Patients w/ stenosis
Ulceration or adhesions
Fecal obstruction
Should you get bulk-forming laxatives with other medications?
No- if you give bulk-forming laxative first wait 4 hours before giving meds. If take meds first wait 2 hours before bulk laxatives
Besides constipation, what are bulk-forming laxatives good for?
Diarrhea
Lowering cholesterol
What is an emollients?
Docusate sodium
WHat is docusate sodium used for?
To avoid straining
after MI, rectal surgery, opiates
1st line for pregnancy (along w/ bulk forming)
MOA of docusate sodium
Surfactant brings water into stool, mixing of aqueous and fatty material within intestine