N+V Flashcards

1
Q

define vomiting?

A

uncontrolled reflex that expels the contents of the stomach through the mouth

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2
Q

define nausea?

A

feeling like you want to be sick – no physical vomiting

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3
Q

define retching?

A

reverse movements (peristalsis) of stomach/ oesophagus and but not actually vomiting

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4
Q

what is a mallor weiss tear?

A
  • Excessive retching and vomiting can cause a tear/ laceration of stomach/ oesophagus
  • Often found near gastro-oesophageal border (near fundus of stomach)
  • Mallory – Weiss tear – small amounts of fresh blood sicked up – need history of previous recent vomiting/ retching
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5
Q

what is boehaaves syndrome?

A

oesophagus is ruptured during severe retching/ vomiting
stomach contents goes through tear and into mediastinum

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6
Q

? can prolonged severe vomiting cause metabolic alkalosis

A

fluid depletion/ dehydration can cause a metabolic alkalosis

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7
Q

what does nausea but no vomiting indicate?

A

increased intracranial pressure

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8
Q

what would sudden onset of vomiting with/without diarrhoea prompt?

A

prompt isolation (barrier nursing) – need infection caution and avoid dissemination to other patients irrespective of exposure history

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9
Q

what is included on history of vomiting?

A
  1. Drinking fluids – ask about nappies/ nappies etc
  2. What does vomit look like – green (bile from stomach), red – other issues, undigested food  oesophageal pouch – regurgitation (no heaving, slightly rotted and undigested food coming up). Gastric juices – gastric outlet obstruction. Vomiting of faecal material  colointestinal/ cologastric fistulae
  3. Volume/ amount
  4. Does it contain blood – what type (RED FLAG)
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10
Q

what type of conditions is prolonged nausea/ vomiting associated to?

A
  • Prolonged nausea and vomiting is usually linked to chronic conditions such as CKD, liver disease, cancers (physical cause or treatment) , pregnancy, GORD (usually resolves after eating), diabetes
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11
Q

what are repeated acute episodes of V/N linked to?

A
  • Can be repeated episodes of acute causes such as migraine, motion sickness
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12
Q

what would nausea and central niggling pain that moves to iliac fossa indicate?

A

appendicitis

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13
Q

what would colickly pain then moves to constant pain and then N/V indicate

A

obstruction

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14
Q

what type of pain would biliary pathology present with?

A

colicky pain

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15
Q

how would pancreatitis present?

A

V+N
central pain then referred back pain
alcohol history

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16
Q

how would renal stones pain present?

A

back pain then refers to groin

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17
Q

what type of pain would be seen in pyelonephritis?

A

back pain - need urine dip to see WCC elevation and inflammation

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18
Q

what is pyelonephritis?

A

kidney infection

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19
Q

what CVS conditions may present as N+V?

A

MI
angina/ aneurysm

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20
Q

what neurological conditions may present with N+V?

A

headache (menigitis, encephalitis, sub arachnoid sub dural bleeds), migraine, raised intra cranial pressure and glaucoma

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21
Q

what is history is needed with potential infectious cause of N+V?

A
  • Ask about recent illnesses (gastroenteritis) in family members, places of work, schools etc
  • Recent travel
  • Diarrhoea associated? Blood/ mucus in stool
  • Recent food history – takeaway, undercooked, out of date etc
  • Food poisoning and infectious bloody diarrhoea (this requires been notified to PHE?)
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22
Q

what would early morning sick and alcohol link?

A

shows alcohol dependence
alcohol excess

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23
Q

when would vomiting occur in diabetics?

A
  • Diabetes type 1: acute vomiting seen in DKA
  • Diabetes T1/T2: chronic vomiting – gastroparesis
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24
Q

why do you need a surgical and medical history within N+V?

A
  • Particularly abdo surgery and IBS
  • At risk of adhesions: inflammation and scarring torsion risk causes by gut mobility
  • Any associated vertigo, gait instability, nystagmus (repetitive, involuntary movement of the eyes) – labyrinth disorders eg vestibular neuronitis as the cause of vomiting
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25
Q

what other general symptoms may present with N+V?

A

General symptoms: dehydration ( decreased skin turgor, sunken eyes, no/ low urine output, dark yellow urine, decreased cap refill, dizzy, confused, lack of tears/ sweat, falls/ difficulty walking, low BP, rapid HR, abnormal labs/ electrolytes

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26
Q

what would reveal tenderness, guarding and rebound in abdo exam?

A

acute abdo - need surgical review asap

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27
Q

what would you look for a neuro exam with a patient presenting with V+N?

A
  • Look for any cranial nerve or gait deficits
  • Nystagmus: disorder of labyrinth system
  • Fundoscopy to assess for papilledema
  • Enlarged discs: increased intracranial pressure and this will stimulate brainstem emesis centres
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28
Q

in gastroparesis what would indicate diabetic autonomic neuropathy?

A

orthostatic hypotension, orthostatic tachycardia, abnormal sweating, delayed bladder emptying

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29
Q

what dental sign would indicate bulimia as cause of V+N?

A

loss of dental enamel - flat teeth

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30
Q

V+N may be the only symptom in elderly and children for what infection?

A

UTI

31
Q

if a women comes in with V+N and at childbearing age, what test must be done?

A

pregnancy test

32
Q

what are antimetrics?

A

anti-sickness meds

33
Q

what is cyclizine?

A

– histamine H1 receptor antagonist

34
Q

when are cyclizine indicated for V+N?

A

pregnancy - small and short dose
surgery prophylaxis

35
Q

what is the action of metoclopramide?

A

D2 receptor anatagonist
prokinetic

36
Q

when are metoclopramide contra-indicated?

A

under 18s
parkinson’s
phaechromocytoma

37
Q

what side effects are seen in metoclopramide?

A

gurning and involuntary face movements

38
Q

what is ondansetron?

A

serontonin 5-HT3 receptor antagonist

39
Q

what is domperidone?

A

D2 receptor antagonist
prokinetic

40
Q

what in the blood can cause N+V?

A
  • Blood: hormones eg pregnancy, alcohol, toxins, meds, infection, increased calcium, poisons
41
Q

what in gut can cause N+V?

A
  • GUT: acid, Abx,IBS, tumour, constipation, heartburn
42
Q

what in brain can cause N+V?

A

headache, meningitis, increased ICP (steroids) , vertigo, motion sickness, anxiety, sight, smells, tinnitus

43
Q

what antiemetics act on gut mucosa?

A

metaclompramide, levomepromazine, ondansetron, promethazine

44
Q

what antiemetic act on the cerebral cortex?

A

dexamethasone

45
Q

what anti-emetic acts on chemoreceptor trigger?

A

haloperidol, metoclopramide, levomepromazone, ondansetron, promethazine

46
Q

what anti emetic acts on vestibular system?

A

cyclizine, hyoscine hydrobromide, promethazine

47
Q

what are non pharmacological mechanisms to assist in N+V management?

A
  • Distractions
  • Avoidance of situations where N&V likely
  • Sea bands
  • Ginger – helps in pregnancy?
  • Avoidance of emetogenic smells
48
Q

what is the MOA of cyclizine?

A

antihistaminic antimuscarnic anti emetic which exerts action on vomiting centre

49
Q

what are the side effects of cyclizine?

A

drowsiness, urinary retention, dry mouth, blurred vision, GI disturbances

50
Q

what is the MOA of metoclopramide?

A

prokinetic anti-emetic and combined D2 receptor antagonist and 5HT4 receptor agonist
- Serotonin 5HT4 receptor agonist: promote intestinal peristalsis, increase gastric emptying an decrease oesophageal reflux

51
Q

what are the side effects of metoclopramide?

A

extrapyramidal effects – more frequent with high doses and in children and young adults due to crossing BBB, hyperprolactinaemia, akathisia – inability to sit still and being very restless, motor and sensory phenomenon

gastric emptying - diarrhoea

52
Q

what is the mhra alert for metoclompramide?

A
  • MHRA alert for risk of neuro adverse effects
53
Q

what is the moa of domperidone?

A

D2 receptor antagonist with some prokinetic action

54
Q

what are the side effects of domperidone?

A

Side effects: rarely GI disturbances, raised prolactin conc
arrthymias

55
Q

what mhra warning does domperidone have?

A
  • MHRA alert due to cardiac safety  only 10mg TDS for 7 days max
    due to arrhythmias
56
Q

what is the moa of prochlorperazine?

A

dopamine antagonist, some muscarinic and antihistaminic effects

57
Q

what are the side effects of prochlorperazine?

A

drowsiness and extrapyramidal

58
Q

where is ondansetron used alot?

A

GI surgery

59
Q

what is the moa of ondansetron?

A

5HT3 receptor antagonist which prevents release of 5HT (serotonin) from enterochromaffin cells in duodenum

60
Q

what are the side effects of ondansetron?

A

mild headache, constipation (give laxative alongside), transient rises of serum aminotransferase

61
Q

what is the MHRA alert for ondansetron?

A
  • MHRA safety alert: prolongation of QTc interval and cardiac arrhythmias
62
Q

what is aprepitant?

A

NK1 receptor antagonist – blocks action of substance P in CTZ

63
Q

what is aprepitant useful in?

A

treating post surgerical N+V and cancer chemoinduced N+V

64
Q

what side effects are seen in aprepitant?

A

hiccups, dyspepsia, diarrhoea, constipation, anorexia, asthenia, headache, dizziness

65
Q

how can dexamethosone help N+v?

A

corticosteroid with anti-emetic properties

66
Q

what side effects can be seen with dexamethasone?

A

Side effects: rare are singular dose but can elevate serum glucose levels, epigastric discomfort, sleep disturbances

67
Q

what is olanzapine?

A

: anti physchotic – has ability to block may different receptors – hence anti emetic properties

68
Q

what are the side effects of olanzapine?

A

Side effects: drowsiness, weight gain, eosinophilia, elevated prolactin

69
Q

what is hyperemesis in pregnancy?

A

unremitting, dehydration risk

70
Q

what is the 1st line management of N+V in pregnancy?

A

cyclizine

71
Q

what are 2nd and 3rd line management of N+V in pregnancy?

A
  • 2nd line: metoclopramide max 5 days
  • 3rd line: corticosteroids IV and taper to pred and lowest dose
72
Q

what are RF for post op N+V?

A

RF: female, non smoker, previous post op N&V, motion sickness, general anaesthesia, type – gynae, gastro, ENT

73
Q
A