N+V Flashcards

1
Q

define vomiting?

A

uncontrolled reflex that expels the contents of the stomach through the mouth

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2
Q

define nausea?

A

feeling like you want to be sick – no physical vomiting

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3
Q

define retching?

A

reverse movements (peristalsis) of stomach/ oesophagus and but not actually vomiting

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4
Q

what is a mallor weiss tear?

A
  • Excessive retching and vomiting can cause a tear/ laceration of stomach/ oesophagus
  • Often found near gastro-oesophageal border (near fundus of stomach)
  • Mallory – Weiss tear – small amounts of fresh blood sicked up – need history of previous recent vomiting/ retching
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5
Q

what is boehaaves syndrome?

A

oesophagus is ruptured during severe retching/ vomiting
stomach contents goes through tear and into mediastinum

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6
Q

? can prolonged severe vomiting cause metabolic alkalosis

A

fluid depletion/ dehydration can cause a metabolic alkalosis

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7
Q

what does nausea but no vomiting indicate?

A

increased intracranial pressure

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8
Q

what would sudden onset of vomiting with/without diarrhoea prompt?

A

prompt isolation (barrier nursing) – need infection caution and avoid dissemination to other patients irrespective of exposure history

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9
Q

what is included on history of vomiting?

A
  1. Drinking fluids – ask about nappies/ nappies etc
  2. What does vomit look like – green (bile from stomach), red – other issues, undigested food  oesophageal pouch – regurgitation (no heaving, slightly rotted and undigested food coming up). Gastric juices – gastric outlet obstruction. Vomiting of faecal material  colointestinal/ cologastric fistulae
  3. Volume/ amount
  4. Does it contain blood – what type (RED FLAG)
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10
Q

what type of conditions is prolonged nausea/ vomiting associated to?

A
  • Prolonged nausea and vomiting is usually linked to chronic conditions such as CKD, liver disease, cancers (physical cause or treatment) , pregnancy, GORD (usually resolves after eating), diabetes
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11
Q

what are repeated acute episodes of V/N linked to?

A
  • Can be repeated episodes of acute causes such as migraine, motion sickness
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12
Q

what would nausea and central niggling pain that moves to iliac fossa indicate?

A

appendicitis

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13
Q

what would colickly pain then moves to constant pain and then N/V indicate

A

obstruction

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14
Q

what type of pain would biliary pathology present with?

A

colicky pain

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15
Q

how would pancreatitis present?

A

V+N
central pain then referred back pain
alcohol history

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16
Q

how would renal stones pain present?

A

back pain then refers to groin

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17
Q

what type of pain would be seen in pyelonephritis?

A

back pain - need urine dip to see WCC elevation and inflammation

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18
Q

what is pyelonephritis?

A

kidney infection

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19
Q

what CVS conditions may present as N+V?

A

MI
angina/ aneurysm

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20
Q

what neurological conditions may present with N+V?

A

headache (menigitis, encephalitis, sub arachnoid sub dural bleeds), migraine, raised intra cranial pressure and glaucoma

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21
Q

what is history is needed with potential infectious cause of N+V?

A
  • Ask about recent illnesses (gastroenteritis) in family members, places of work, schools etc
  • Recent travel
  • Diarrhoea associated? Blood/ mucus in stool
  • Recent food history – takeaway, undercooked, out of date etc
  • Food poisoning and infectious bloody diarrhoea (this requires been notified to PHE?)
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22
Q

what would early morning sick and alcohol link?

A

shows alcohol dependence
alcohol excess

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23
Q

when would vomiting occur in diabetics?

A
  • Diabetes type 1: acute vomiting seen in DKA
  • Diabetes T1/T2: chronic vomiting – gastroparesis
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24
Q

why do you need a surgical and medical history within N+V?

A
  • Particularly abdo surgery and IBS
  • At risk of adhesions: inflammation and scarring torsion risk causes by gut mobility
  • Any associated vertigo, gait instability, nystagmus (repetitive, involuntary movement of the eyes) – labyrinth disorders eg vestibular neuronitis as the cause of vomiting
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25
what other general symptoms may present with N+V?
General symptoms: dehydration ( decreased skin turgor, sunken eyes, no/ low urine output, dark yellow urine, decreased cap refill, dizzy, confused, lack of tears/ sweat, falls/ difficulty walking, low BP, rapid HR, abnormal labs/ electrolytes
26
what would reveal tenderness, guarding and rebound in abdo exam?
acute abdo - need surgical review asap
27
what would you look for a neuro exam with a patient presenting with V+N?
- Look for any cranial nerve or gait deficits - Nystagmus: disorder of labyrinth system - Fundoscopy to assess for papilledema - Enlarged discs: increased intracranial pressure and this will stimulate brainstem emesis centres
28
in gastroparesis what would indicate diabetic autonomic neuropathy?
orthostatic hypotension, orthostatic tachycardia, abnormal sweating, delayed bladder emptying
29
what dental sign would indicate bulimia as cause of V+N?
loss of dental enamel - flat teeth
30
V+N may be the only symptom in elderly and children for what infection?
UTI
31
if a women comes in with V+N and at childbearing age, what test must be done?
pregnancy test
32
what are antimetrics?
anti-sickness meds
33
what is cyclizine?
– histamine H1 receptor antagonist
34
when are cyclizine indicated for V+N?
pregnancy - small and short dose surgery prophylaxis
35
what is the action of metoclopramide?
D2 receptor anatagonist prokinetic
36
when are metoclopramide contra-indicated?
under 18s parkinson's phaechromocytoma
37
what side effects are seen in metoclopramide?
gurning and involuntary face movements
38
what is ondansetron?
serontonin 5-HT3 receptor antagonist
39
what is domperidone?
D2 receptor antagonist prokinetic
40
what in the blood can cause N+V?
- Blood: hormones eg pregnancy, alcohol, toxins, meds, infection, increased calcium, poisons
41
what in gut can cause N+V?
- GUT: acid, Abx,IBS, tumour, constipation, heartburn
42
what in brain can cause N+V?
headache, meningitis, increased ICP (steroids) , vertigo, motion sickness, anxiety, sight, smells, tinnitus
43
what antiemetics act on gut mucosa?
metaclompramide, levomepromazine, ondansetron, promethazine
44
what antiemetic act on the cerebral cortex?
dexamethasone
45
what anti-emetic acts on chemoreceptor trigger?
haloperidol, metoclopramide, levomepromazone, ondansetron, promethazine
46
what anti emetic acts on vestibular system?
cyclizine, hyoscine hydrobromide, promethazine
47
what are non pharmacological mechanisms to assist in N+V management?
- Distractions - Avoidance of situations where N&V likely - Sea bands - Ginger – helps in pregnancy? - Avoidance of emetogenic smells
48
what is the MOA of cyclizine?
antihistaminic antimuscarnic anti emetic which exerts action on vomiting centre
49
what are the side effects of cyclizine?
drowsiness, urinary retention, dry mouth, blurred vision, GI disturbances
50
what is the MOA of metoclopramide?
prokinetic anti-emetic and combined D2 receptor antagonist and 5HT4 receptor agonist - Serotonin 5HT4 receptor agonist: promote intestinal peristalsis, increase gastric emptying an decrease oesophageal reflux
51
what are the side effects of metoclopramide?
extrapyramidal effects – more frequent with high doses and in children and young adults due to crossing BBB, hyperprolactinaemia, akathisia – inability to sit still and being very restless, motor and sensory phenomenon gastric emptying - diarrhoea
52
what is the mhra alert for metoclompramide?
- MHRA alert for risk of neuro adverse effects
53
what is the moa of domperidone?
D2 receptor antagonist with some prokinetic action
54
what are the side effects of domperidone?
Side effects: rarely GI disturbances, raised prolactin conc arrthymias
55
what mhra warning does domperidone have?
- MHRA alert due to cardiac safety  only 10mg TDS for 7 days max due to arrhythmias
56
what is the moa of prochlorperazine?
dopamine antagonist, some muscarinic and antihistaminic effects
57
what are the side effects of prochlorperazine?
drowsiness and extrapyramidal
58
where is ondansetron used alot?
GI surgery
59
what is the moa of ondansetron?
5HT3 receptor antagonist which prevents release of 5HT (serotonin) from enterochromaffin cells in duodenum
60
what are the side effects of ondansetron?
mild headache, constipation (give laxative alongside), transient rises of serum aminotransferase
61
what is the MHRA alert for ondansetron?
- MHRA safety alert: prolongation of QTc interval and cardiac arrhythmias
62
what is aprepitant?
NK1 receptor antagonist – blocks action of substance P in CTZ
63
what is aprepitant useful in?
treating post surgerical N+V and cancer chemoinduced N+V
64
what side effects are seen in aprepitant?
hiccups, dyspepsia, diarrhoea, constipation, anorexia, asthenia, headache, dizziness
65
how can dexamethosone help N+v?
corticosteroid with anti-emetic properties
66
what side effects can be seen with dexamethasone?
Side effects: rare are singular dose but can elevate serum glucose levels, epigastric discomfort, sleep disturbances
67
what is olanzapine?
: anti physchotic – has ability to block may different receptors – hence anti emetic properties
68
what are the side effects of olanzapine?
Side effects: drowsiness, weight gain, eosinophilia, elevated prolactin
69
what is hyperemesis in pregnancy?
unremitting, dehydration risk
70
what is the 1st line management of N+V in pregnancy?
cyclizine
71
what are 2nd and 3rd line management of N+V in pregnancy?
- 2nd line: metoclopramide max 5 days - 3rd line: corticosteroids IV and taper to pred and lowest dose
72
what are RF for post op N+V?
RF: female, non smoker, previous post op N&V, motion sickness, general anaesthesia, type – gynae, gastro, ENT
73