Myopathic Disorders

Question 1

what are myopathies?

Answer 1

disorders of the muscle tissue

Question 2

progressive muscular dystrophies cause degeneration of

Answer 2

skeletal muscle fibers

Question 3

what are symptoms of metabolic myopathies?

Answer 3

cramps, muscle fatigue on exertion, proximal weakness, symptoms from other body systems

Question 4

what are symptoms of myotonic syndromes?

Answer 4

stiffness, limitation of movement (esp. in cold), difficulty releasing grip

Question 5

hyperkalemic periodic paralysis is caused by the mutation of

Answer 5

Na channels

Question 6

symptoms of hyperkalemic periodic paralysis?

Answer 6

weakness/paralysis
occurs intermittently
decreased or absent reflexes
flaccid muscles

Question 7

what are the triggers of hyperkalemic periodic paralysis?

Answer 7

rest after exercise
fasting
exposure to cold
eating potassium

Question 8

What is rhabdomyolysis and what can cause it?

Answer 8

• Death of muscle fibers and release of its content into the bloodstream
• Caused by damage skeletal muscles
• Status epilepticus, injury, overexertion, drugs, alcohol abuse

Question 9

what are the symptoms of Duchenne Muscular dystrophy?

Answer 9

• weakness of pelvic/lower extremities
• Deformed legs, inability to keep legs straight
• Pulmonary infections, heart failure, anemia
• Symptoms appear in preschool children
• Difficulty getting up from squatting position (Gower’s sign)