myoglobin and haemoglobin

Question 1

what is the main role of myoglobin?

Answer 1

to store oxygen in the tissues of the body

Question 2

what is the main role of haemoglobin ?

Answer 2

to acquire oxygen in the lungs and deliver it to the tissues

Question 3

what are the two major components of a myoglobin or haemoglobin molecule

Answer 3

haem and the globin fold

Question 4

what is a haem group and what are its properties ?

Answer 4

haem is a prosthetic group or a cofactor. its made up of 4 pyrole rings, the iron in the centre binds 6 substituents. 4 nitrogens from the haem, 1 nitrogen from a histadine and an oxygen molecule

Question 5

how many subunits make up myoglobin vs haemoglobin?

Answer 5

myoglobin is a monomer
haemoglobin is a tetromer

Question 6

what secondary structure dominates globin proteins

Answer 6

alpha helices

Question 7

what is the role of HIS- E7 in myoglobin

Question 8

Myoglobin is O2 saturated at a ____ pO2, and releases O2 at a very ___ pO2

Answer 8

O2 saturated at a low pO2, releases oxygen at a high partial oxygen pressure.

Question 9

what is the maximum number of O2 molecules that may be bound to a haemoglobin tetromer

Answer 9

4

Question 10

what are the changes that occur upon oxygen binding and release

Answer 10

oxygen binding to fe brings fe into the plane of the haem.