Myocardium & Skeletal muscle dis.

Question 1

what are the 2 types of biomarkers

Answer 1

Enzymes and proteins

Question 2

Early markers

Answer 2

Total CK & CKMB

Question 3

What is CKMB specific to?

Answer 3

Heart

Question 4

What does CK stand for?

Answer 4

Creatine kinase

Question 5

Time intervals for when CKMB is released

Answer 5

2-6hrs

Question 6

Time intervals for when CKMB peaks

Answer 6

12-16hrs

Question 7

Time intervals for when CKMB is normalised

Answer 7

36hrs

Question 8

what are the mid markers?

Answer 8

AST

Question 9

Time intervals for when AST is released

Answer 9

6-12hrs

Question 10

Time intervals for when AST peaks

Answer 10

24-48hrs

Question 11

Time intervals for when AST is normalised

Answer 11

4-7 days

Question 12

What are the late markers?

Answer 12

LDH & HBDH

Question 13

What is HBDH

Answer 13

LDH 1 + LDH 2

Question 14

Time intervals for when LDH is released

Answer 14

10HRS

Question 15

Time intervals for when LDH peaks

Answer 15

36-48HRS

Question 16

Time intervals for when LDH is normalised

Answer 16

7-12 days

Question 17

Time intervals for when HBDH is released

Answer 17

10-12HRS

Question 18

Time intervals for when HBDH peaks and normalises

Answer 18

Both 2-3 weeks

Question 19

What are the protein markers?

Answer 19

Troponin & Myoglobin

Question 20

What the main types of troponin?

Answer 20

Troponin I and T

Question 21

Time intervals for when cTnI is released

Answer 21

2-8hrs

Question 22

Time intervals for when cTnI peaks

Answer 22

12hrs

Question 23

Time intervals for when cTnI is normalised

Answer 23

5-7 (10) days

Question 24

cTnI is ideal for

Answer 24

cardiac biomarkers

Question 25

Why is myoglobin important?

Answer 25

it's sensitive to damage and it's not specific

Question 26

Troponin I: 0.04 – 0.4ng/ml – if >0.4

Answer 26

It is MI

Question 27

Troponin I: 0.04 – 0.4ng/ml – if it's between 0.04-0.4

Answer 27

it is unstable angina

Question 28

To be considered a MI: time and what should not relieve when...

Answer 28

should late at least for 30mins, should not be relieved by nitro-glycerine or rest

Question 29

unstable angina is ischemia

Answer 29

True

Question 30

myocardial infarction is when necrosis occurs

Answer 30

True

Question 31

what is found during Trauma and infection/ myositis? 4 subs

Answer 31

CK, AST, LDL, myoglobin is found and Increased.

Question 32

when does Duchenne Muscular dystrophy start from?

Answer 32

Starts at a young age, 5years onwards

Question 33

Is Duchenne Muscular dystrophy X linked or Y linked?

Answer 33

X linked

Question 34

what subs. indicates Duchenne Muscular dystrophy? 4 subs

Answer 34

CK & AST are high, cholinesterase and aldolase