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BIOCHEM: CASE STUDIES > Myocardium & Skeletal muscle dis. > Flashcards

Myocardium & Skeletal muscle dis. Flashcards

1
Q

what are the 2 types of biomarkers

A

Enzymes and proteins

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2
Q

Early markers

A

Total CK & CKMB

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3
Q

What is CKMB specific to?

A

Heart

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4
Q

What does CK stand for?

A

Creatine kinase

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5
Q

Time intervals for when CKMB is released

A

2-6hrs

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6
Q

Time intervals for when CKMB peaks

A

12-16hrs

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7
Q

Time intervals for when CKMB is normalised

A

36hrs

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8
Q

what are the mid markers?

A

AST

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9
Q

Time intervals for when AST is released

A

6-12hrs

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10
Q

Time intervals for when AST peaks

A

24-48hrs

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11
Q

Time intervals for when AST is normalised

A

4-7 days

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12
Q

What are the late markers?

A

LDH & HBDH

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13
Q

What is HBDH

A

LDH 1 + LDH 2

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14
Q

Time intervals for when LDH is released

A

10HRS

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15
Q

Time intervals for when LDH peaks

A

36-48HRS

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16
Q

Time intervals for when LDH is normalised

A

7-12 days

17
Q

Time intervals for when HBDH is released

A

10-12HRS

18
Q

Time intervals for when HBDH peaks and normalises

A

Both 2-3 weeks

19
Q

What are the protein markers?

A

Troponin & Myoglobin

20
Q

What the main types of troponin?

A

Troponin I and T

21
Q

Time intervals for when cTnI is released

A

2-8hrs

22
Q

Time intervals for when cTnI peaks

A

12hrs

23
Q

Time intervals for when cTnI is normalised

A

5-7 (10) days

24
Q

cTnI is ideal for

A

cardiac biomarkers

25
Q

Why is myoglobin important?

A

it’s sensitive to damage and it’s not specific

26
Q

Troponin I: 0.04 – 0.4ng/ml – if >0.4

A

It is MI

27
Q

Troponin I: 0.04 – 0.4ng/ml – if it’s between 0.04-0.4

A

it is unstable angina

28
Q

To be considered a MI: time and what should not relieve when…

A

should late at least for 30mins, should not be relieved by nitro-glycerine or rest

29
Q

unstable angina is ischemia

A

True

30
Q

myocardial infarction is when necrosis occurs

A

True

31
Q

what is found during Trauma and infection/ myositis? 4 subs

A

CK, AST, LDL, myoglobin is found and Increased.

32
Q

when does Duchenne Muscular dystrophy start from?

A

Starts at a young age, 5years onwards

33
Q

Is Duchenne Muscular dystrophy X linked or Y linked?

A

X linked

34
Q

what subs. indicates Duchenne Muscular dystrophy? 4 subs

A

CK & AST are high, cholinesterase and aldolase

BIOCHEM: CASE STUDIES (3 decks)

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