Myocarditis Flashcards
what heart disease is charaterized by abnormal heart muscle not from CAD, HTN, Valve disease, or CHD?
cardiomyopathies
what is the most common cardiomyopathy, and its cause
dilated, idiopathic
inability to contract and expel blood is a ____ side heart problem, while cor pulmonale is a ____ side heart problem
Left, Right
heart disease associated with enlarged atria
Cardiomyopathy
what disease has LV cavity increases with not HTN or Hypertrophy and has endocardial fibrosis
Cardiomyopathy
what are the ABCDPIG causes of Dilated CM
Alcohol, beri beri, Cox, Drugs, Pregs, Idiopathic, genetic
Most common cause of dilated cardiomyopathy, and thus most common cause of HF due to systolic dysfunction. LVEF<35% from CAD
Ischemic CM
Treat this disease with ASA, statins, beta blockers, ACE, Loops, and K-sparring diuretics
Ischemic CM
associated with Acetaldehyde damage, leads to prolonged QT.
alcoholic CM, abstain
what disease has HF late in pregnancy (within 1 month of birth)
Peripartum Cardiomyopathy
when can you wean a patient with perpartum CM off therapy
LVEF>50%
Broken heart syndrome with systolic apical ballooning
Takotsubo
what CM leads to a troponin level 7x elevated, ST elevation, and with apical ballooning pattern
Takotsubo
Which CM has SXS of both LHF and RHF, with heaves and a shifted PMI
Dilated cardiomyopathy
What can you see in a CBC & CMP in Dilated CM?
CBC = anemia (high output state) CMP = hyponatriemia, LFTs, electrolyte inbalance
What can you see in a CXR, EKG, Cardiac Cath in DCM?
CXR = cardiomegaly, pulm congestion, Kerley B lines,
EKG = LVH, conduction delay, arrythmias.
Cardiac Cath = exclude ischemia
What disease do you treat like HF (Ace/Arbs, Beta blockers, aldostrone ant, Diuretics, Nitro, Sacubitril-valsartan)?
Dilated Cardiomyopathy.
If your patients has ischemic dilated CM what do you do?
Revascularization
How do ACE-I help DCM
reduce preload, afterload by vasodilation. Prevent cardiac remodeling.
What are the side effects of an ACE?
CHAA, Cough, hyperK, angio edema, acute nephritis
How do Beta blockers help DCM
In EF<40%, can reduce catecholamine effects and slow HR = increased filling time, while decreasing afterload. This allows better coronary perfussion.
When should you not give beta blockers to a patient with DCM
HR< 50, 2/3 degree heart block, asthma, COPD
What are surgical options for DCM
LVAD, cardiac resynchronization therapy if EF<35% or Bundle branch block on EKG.
most common cause of DCM
idiopathic
most common cause of HCM
Genetics, athlete that had SCD
What disease has abnormal thickening of the intramural coronarys
HCM
A hypercontractile LVH with a small cavity is
HCM
what disease is associated with coronary compression during systole, and impaired filling in diastole, and with SAM (mital valve sytolic anterior motion)
HCM
How does LVOTO affect preload, afterload, and inotropy in HCM
decrease preload & afterload but increased inotrophy
what disease leads to SCD from venticular arryhthmias?
HCM
How thick can the septal wall get in HCM
> 30 m, which leads to hypoperfusion, and syncope
what disease do you see a double apical impulse (S4), and S2, and a crescendo-decrescendo murmur.
HCM
TTE is used to diagnose what disease
HCM
What are the first line meds for sxs arrythmias with HCM
beta blockers or anti-arrythmics (sotalol, amiodarone)
what do you give a patient with A-fib and HCM
anticoagulants
how does a beta blocker help in HCM
reduces inotrophy, 02 demands, and increases LV fill time
if a Beta blocker doesnt work for HCM, whats next?
discontinue BB and give CCM like verapamil
If a beta blocker or a CCM didnt help a patient with HCM, whats next
give Disopyramide (antiarrhythmic), strong anticholinergic effect & prolonged QT
what are the surgical treatments for HCM
Surgical septal myectomy (needs cardiopulm bypass)
Alcohol ablation: ablate SAM (mitral valve systolic anterior motion)
What type of murmur do you see in HCM
crescendo-descendo in LLD position
What CM is associated with non-dilation, non-hypertrophic disease but has amyloidosis
RCM - with bi-atrial enlargement (from impaired LV filling)
What are some main causes of RCM
1st = idopathic (associated with Loefflers Eosinophilia)
Amyloidosis, Sarcoidosis, cancer, radiation induced, hemochromatosis.
What is the most common worldwide cause of RCM
Leofflers eosinophiliac endocarditis
What disease shows RHF sxs (LE pitting, edema, hepatomegaly, ascites, JCD), Cardiac cachexia, and periorbital purpura
RCM
What disease gives a positive Kussmaul’s sign
Kussmauls = JVD during inspiration.
RCM
What is the front line daignosis test for RCM
Echo: with infiltrate disease, you can see concentric LVH, and specific strain patterns. without amyloids, see dilated atria
What type of pattern can be seen in a Cardiac MR with RCM
Late Gadolinium Enhancement (LGE)
What lab tests can show that a patient has RCM?
CBC = eosinophilia smearing CMP = LFTs and Fe conc. BNP = elevated in RCM not in restrictive pericarditis EKG = ST changes in 90% of patients and low voltage
What tests will differentiate between RCM and restrictive pericarditis
Cardiac cath
Ventricular biopsy: see infiltrates,
BNP: elevated in RCM
CBC = Leofflers eosiniophilia
What are the medical goals and tx for RCM
Goal: reduce LV filling pressure w/o losing CO
Meds = beta blockers and CCB (increase LV filling time)
Diuretics (reduce preload)
ACE/ARB (poorly tolerated>
Anticoag - if A-fib
How do you treat amyloids, sarcoidosis, or hemochromatosis in RCM
Amyloids = chemo Sarcoidosis = corticosteroids Hemochrom = phlebotomy
What disease is associated with Periorbital purpura
RCM
What disease is associated with cardiac cachexia
Amyloidosis of RCM
Inflammatory infiltrate of myocardium with necrosis not from ischemia or CAD
Dallas Criteria
Causes of Myocarditis
Idiopathic or viral
Chagas, HIV, autoimmune
what percentage of Myocarditis leads to DCM
1/3
What disease presents with Flu like or URI sxs?
Myocarditis
what are the acute signs of decompensated HF in myocarditis
S3, edema, tachy
Pericardial friction rub with pericarditis
What is the Gold stnd for diagnosing Myocarditis
Endomyocardial Biopsy
Why do you do an Echo and Cardiac MR when suspecting Myocarditis
Echo = rule out HF
Cardiac MR = rule out ischemic CM
What disease can be diagnosed with serum viral titers
Myocarditis
What is the common tx for Myocarditis
Supportive, most recover.