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Key Points > Myeloma > Flashcards

Myeloma Flashcards

1
Q

Myeloma

A

Cancer of the plasma cells i.e. a B lymphocyte that produce antibodies

Genetic mutation causing them to rapidly and uncontrollably divide

Produce lots of one kind of antibody

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2
Q

Myeloma differentials

A

Myeloma

Multiple Myeloma

Monoclonal gammopathy of undetermined significance (MGUS)

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3
Q

Four Key Features

A

CRAB

elevated Calcium

Renal failure

Anaemia (normocytic normochromic) from replacement of bone marrow

Bone lesions/pain

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4
Q

Screening Ix

A

FBC (low white blood cell count)

Calcium (raised)

ESR (raised)

Plasma viscosity (raised)

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5
Q

Suspected Ix (Bloods)

A

“BLIP”

Bence Jones protein (urine electrophoresis)

serum-free Light-chain assay

serum Immunoglobulins

serum Protein electrophoresis

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6
Q

Suspected Ix (other)

A

Bone marrow biopsy

Whole body MRI/CT/Skeletal survey

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7
Q

Treatment

A

MDT approach

Combination chemotherapy

Bisphosphonates

Radiotherapy

Orthopaedic surgery/cement augmentation

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Key Points (6 decks)

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