Myeloid/Lymphoid Neoplasms with Eosinophilia

Question 1

CHIC2 deletion by FISH is used as a surrogate for what rearrangement?

Answer 1

FIP1L1-PDGFRA fusion gene

Question 2

Peripheral blood film shows many morphologic abnormalities of eosinophils, including of size, granulation, and nuclear lobulation (panels A-B).

The bone marrow exhibited 45% to 55% eosinophilic hyperplasia and 30% of myeloid blast cells (panel C; blue arrows show blast cells). Abnormal eosinophils with dysplastic granules were present.

What is rearrangement a possible rearrangment?

Answer 2

FIP1L1-PDGFRA

Question 3

This patient exhibited eosinophilia and had cytogenetic analysis showing 46,XY,t(8;9)(p11.2;q33.2) karyotype.

What rearrangement was present?

Answer 3

FGFR1 rearrangement

. FGFR1-related myeloid neoplasms with eosinophilia are rare.

Question 4

Describe the morphology of eosinophils often encountered in Myeloproliferative neoplasm with eosinophilia associated with FIP1L1-PDGFRA

Answer 4

Some of the eosinophils have sparse granulation and/or show abnormal nuclear segmentation.