Myeloid Disorders

Question 1

Translocation in CML

Answer 1

9, 22

Philadelphia Chr

Question 2

Four classic substypes of myeloproliferative disorders

Answer 2

Polycythemia Vera
Essential Thrombocytosis
Chronic Myelogenous Leukemia
Agnogenic Myeloid Metaplasia (Myeloid Fibrosis)

Question 3

Philadelphia chromosome turns on ____

Answer 3

BCR-ABL gene

Tyrosine Kinase

Question 4

Three physical exam findings that support a diagnosis of physical diagnsois

Answer 4

splenomegaly
ecchymoses
early satiety

Question 5

Laboratory findings of CML

Answer 5

Elevated WBC with all granulocyte precursors in the peripheral blood
More RBC, platelets, eosinophils, and basophils

Question 6

Polycythemia vera is associated with a ______ mutation

Answer 6

Jak2

Question 7

What should be elevated to diagnose CLL?

Answer 7

ABSOLUTE LYMPHOCYTE NUMBER

NOT PERCENTAGE

Question 8

Translocation favorable in AML? unfavorable?

Answer 8

FAVORABLE – 15, 17

Unfavorable – 9, 22 or multiple chromosomal defects

Question 9

Acute Promyelocytic Leukemia is characterized by the _____ mutation

Answer 9

15, 17

Question 10

Classic example of a drug that causes aplastic

Answer 10

Chloramphenicol

Question 11

Paroxysmal nocturnal hemoglobinuria is associatd with an acquired mutation of…

Answer 11

PIG-A gene

Decreases CD55 and CD59