Mycoplasma Pneumonia Flashcards
Disease
Atypical pneumonia
Properties
Smallest free living organism
Devoid of cell wall
Pleomorphic
Can be grown on artificial media(not used in diagnostic purpose)
Grow slowly (at least 1 week)
Fried-egg appearance on media
Penicillin or cephalosporin ineffective
Size
Smallest free living
Cell wall
Absent
Peculiarity of cell membrane
Contain cholesterol
Media
Not used for diagnosis.
Can be grown on artificial media that takes 1 weeks.
Appearance:Fried egg
Pathogen for
Human
Transmission
Respiratory droplets
Damage respiratory tract by
Hydrogen peroxide
Serotype
1
Immunity
Incomplete
Autoimmunity
Against rbc,brain,lung,liver cell
Cold agglutinin
Autoantibody (IgM) against type O red cell
Age
5-15 years
Prevalence
Most common cause of atypical pneumonia
Causes of atypical pneumonia
Legionellla pneumophila
Chlamydia pneumonia
Chlamydia psittaci
Coxiella burnetii
Virus(Adenovirus,influenza virus)
Why called atypical?
1)cannot be isolated on routine media
2)does not resemble pneumococcal pneumonia
C/F
Nonproductive cough
Sore throat
Earache
Small amount of whitish,nonbloody sputum.
Constitutional symptoms -
Fever
Headache
Malaise
Myalgia
Extrapulmonary manifestations
Stevens-Johnson syndrome
Erythema multiforme
Mucositis
Raynaud’s phenomenon
Cardiac Arrythmia
Arthralgia
Hemolytic anemia
Neurological-
Encephalitis
Guillain-Barre syndrome
Lab diagnosis
Not made by culture.
Regular media reveals only normal flora.
PCR
Cold agglutinin titer(1:128 indicate recent infection)
CFT
ELISA
False positive cold agglutinin
Influenza virus
Adenovirus
Mycoplasma hominis
PID
Mycoplasma genitalium
NGU
Ureaplasma Urealyticum
NGU
Produce urea
