Mycophenalate

Question 1

MYCOPHENOLATE:
What is indications?

Answer 1

prophylaxis of organ transplantation acute rejection

Question 2

Mycophenolate:
what are monitoring requirements?

Answer 2

Monitor full blood count every week for 4 weeks then twice a month for 2 months then every month in the first year (consider interrupting treatment if neutropenia develops).

Question 3

Mycophenolate:
What does the MHRA advise for pregnancy prevention?

Answer 3

pregnancy in females of child-bearing potential before treatment—2 pregnancy tests 8–10 days apart are recommended. Women should use at least 1 method of effective contraception before and during treatment, and for 6 weeks after discontinuation—2 methods of effective contraception are preferred. Male patients or their female partner should use effective contraception during treatment and for 90 days after discontinuation.

Question 4

is it safe in breastfeeding?

Answer 4

No- present in milk

Question 5

What are important side effects?

Answer 5

Cases of pure red cell aplasia

Question 6

what are monitoring requirements?

Answer 6

Bone marrow suppression signs ( infection or unexplained bruising or. bleeding)

serum immunoglobulin levels if recurrent infections develop

Broncheiastasis or pulmonary fibrosis if persistent respiratory symptoms.