Myasthenia Gravis Flashcards

1
Q

MG: Signs/Symptoms

A

ENT (CN 5, 7, 9-12): diplopia, ptosis, dysphagia, difficulty chewing, dysarthria
Heart: HTN, 1 degree AV block, a fib, myocarditis, CM, diastolic dysfunction
Lungs: dyspnea (2/2 respiratory muscle compromise)
Neuro: muscle weakness
Other: hyperthyroid, RA, SLE, anemia

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2
Q

MG: Diagnosis

A

Tensilon test
Nerve stimulation test
Antibody immunoassay

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3
Q

MG: Pathophysiology

A

Autoimmune destruction of postsynaptic nicotinic Ach receptors at NMJ leads to muscle weakness - worsens with activity and improves with rest

MG develops in 30-65% of thymoma anterior mediastinal masses

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