mutations

Question 1

burkett lymphoma

Answer 1

C myc amplification 8:14

lately infected with EBV

Question 2

Follicular

Answer 2

14;18 translocation. amplification of BCL2

Question 3

TTP

Answer 3

ADAMST13

Question 4

DLBCL

Answer 4

BCL6

Question 5

HHV8

Answer 5

primary effusion lymphoma. a type of DLBCL

Question 6

waldeyer ring

Answer 6

Seen in DLBCL

Question 7

EBV

Answer 7

burkett lymphoma
extra nodal NK/T cell lymphoma
thymic carcinoma
HLH (EBV activated) “hemophagocytic lymphhistiocytosis”

Question 8

MLL2

Answer 8

Follicular lymphoma found in 90%

Question 9

CD23+ CD5 -

Answer 9

Follicular lymphoma

Question 10

mandible involvement

Answer 10

endemic Burkett

Question 11

mass involving ilioceccum or peritoneum

Answer 11

Sporadic burkett

Question 12

multiple myeloma poor outcome

Answer 12

13q, 17q deletions

Question 13

rouleaux formation

Answer 13

can be seen in Multuple myeloma or lupus. isn’t super specific

when RBCs stick together

Question 14

multiple myeloma good outcome

Answer 14

translocation of Cyclin D1

Question 15

solitary myeloma location

Answer 15

oronasopharynx or nasal sinuses most times. and lungs

Question 16

MYD88

Answer 16

lymphoplasmocytic lymphoma

Question 17

mantle zone lymphoma

Answer 17

11;14 cyclin D1 over expression (from chromosome 11)

Question 18

Cd23- CD5 +

Answer 18

Mantle zone lymphoma

Question 19

autoimmune infections or chronic inflammation predisposes you to this condition

Answer 19

marginal cell lymphoma

Question 20

BRAF mutation

Answer 20

Hairy cell leukemia

pulmonary lagerhands cell histiocytosis

Question 21

CD11c

Answer 21

hairy cell leukemia

Question 22

massive splenomegaly

Answer 22

hairy cell leukemia

Question 23

TRAP (tartrate resistant acid phosphatase)

Answer 23

seen in hairy cell leukemia

Question 24

ALK

Answer 24

Anaplastic large cell lymphoma
good prognosis
T cell tumor
CD30 +

Question 25

Cloverleaf / flower cells

Answer 25

Adult T cell leukemia/lymphoma associated with HTLV-1

Question 26

increased incidence of rheumatologic disorders

Answer 26

Large granular lymphocytic leukemia | neutropenia and anemia dominate the clinical picture

Question 27

20% myeloid blasts in bone

Answer 27

AML

Question 28

non specific esterase +

Answer 28

monocytes

Question 29

AML best prognosis

Answer 29

15;17 translocation. acute promylocytic leukemia

Question 30

RPS14

Answer 30

loss of this is a hallmark of Mylodysplastic syndromes

Question 31

9:22 translocation

Answer 31

``` CML = good prognosis ALL = bad prognosis ```

Question 32

polycythemia vera mutation

Answer 32

JAK2

Question 33

catch 22

Answer 33

``` Di george syndrome associated with thymic hypoplasia Cardiac abnormalities abnormal facies thymic hypoplasia cleft palate hypoparathyroid Chromosome 22 ```

Question 34

myasthenia gravis

Answer 34

thymic hyperplasia

Question 35

hereditary spherocytosis inharitence

Answer 35

Auto Dom or compound heterozygote

Question 36

G6PD inharatence

Answer 36

recessive X linked

Question 37

worse prognosis for CLL

Answer 37

NOTCH 1 mutation. ZAP 70 mutations lack of somatic hypermutation deletions of 11q and 17p

Question 38

Extranodal NK T cell lymphoma rare area of presentation in males

Answer 38

testicles.

Question 39

autoimmune conditions predisposes you to this in the thymus

Answer 39

thymic hyperplasia -> will have more B cells in there

Question 40

horseshoe cells

Answer 40

aplastic large cell lymphoma

Question 41

cloverleaf cells

Answer 41

HTLV1

Question 42

mpl2 and JAK2

Answer 42

essential thrombocytosis and primary myelofirbosis

Question 43

CD46 -

Answer 43

look for in atypical HUS

Question 44

CD55

Answer 44

"decay accelerating factor" | found in paroxysmal nocturnal hemoglobinuria

Question 45

Romiplostim

Answer 45

recombinant thrombopoeitin

Question 46

12;21

Answer 46

BALL

Question 47

NOTCH 1 in kids

Answer 47

T ALL

Question 48

STAT 3

Answer 48

Large granular lymphocytic leukemia