Mutations Flashcards
Which medication is indicated for CLL with a 17P deletion?
Imbruvica
Which medications are used for BRAF V600E positive cancers?
- Braftovi
- Zelboraf
- Mekinist (also for V600K)
- Tafinlar (also for V600K, but melanoma only V600E when alone)
- Mektovi/Braftovi (also for V600K)
- Cotellic (also for V600K)
Which medications are used for BRAF V600K mutated cancers?
- Mekinist
- Tafinlar in combination with Mekinist
- Mektovi/Braftovi
- Cotellic (approved only in in combo with Zelboraf to also cover BRAF V600E)
Medications for BRCA mutated cancers have generic names ending in parib, name 4 brand names.
Talzenna, Lynparza, Rubraca and Zejula
There is a class warning of Myeloid Displastic Syndrome/Acute Myeloid Leukemia (AML)
Which medications are used for EGFR Exon 19 deletions or Exon 21 mutations?
- Iressa
- Tarceva (Exon 21 is L858)
- Vizimpro (Exon 21 is L858)
- Tagrisso
- (Exon 21 is L858)
- (previously treated with EGFR T790M)
Which medication is used for follicular lymphoma with a EZH2 mutation?
Tazverik
Which medications are used for AML that is FLT3+?
Rydapt and Xospata
Name 2 of the medications that are used in HER2 + cancers.
Nerlynx and Tykerb
Which medication is used for AML with an IDH2 mutation?
Idhifa
Which medications were recently approved for lung cancer with MET mutations?
- Retevmo
- Tabrecta (with the mutation on exon 14)
Which medications are used for CML (and others) with Philadelphia Chromosome positive dx?
- Bosulif
- Sprycel
- Tasigna
- Iclusig (and/or T3151+)
Which oncology med is used for PIK2CA mutated tumors?
Piqray
Which AML medication is indicated with an R132 mutation?
Tibsovo
Which drug is indicated for metastatic NSCLC with an ALK+ or ROS+ mutation?
Xalcori 250mg PO BID
avoid grapefruit
may cause vision disorders, dizziness
