MUST KNOW!!!!!!!!!! Flashcards
Grossly: Solid, airless lungs
Microscopically:
Pink necrotic cellular debris
Increased neutrophils
HYALINE MEMBRANE DISEASE
Cataract Deafness Mental retardation PDA Blueberry muffin baby
CONGENITAL RUBELLA SYNDROME
What test determines whether respiration took place on a newborn before death?
FODERE’S TEST/ HYDRO STATIC TEST
What test involves floating of the stomach in water to determine the presence of air?
BRESLAU’S TEST
Cause by Vascular endothelial growth factor(VEGF)
Retinopathy of prematurity
Bronchopulmonary dysplasia
Decrease in alveolar septation
COMPLICATIONS OF OXYGEN THERAPY
Breakdown of mucosal barrier function permits transluminal migration of bacteria?
NECROTIZING ENTEROCOLITIS
Bloody stools
Abdominal distention
Shock develop rapidly due to bleeding
Pneumatosis intestinalis (gas within intestinal walls)
Leading to bowel infarction and strictures
NECROTIZING ENTEROCOLITIS
Accumulation of edema fluid in the fetus during intrauterine growth?
FETAL HYDROPS
Prevention of Immune hydrops?
Administration of RhIg Ig to negative mothers at 28 weeks AOG Within 72 hours of delivery
Hyperplasia of bone marrow
Erythroblastosis fetalis
Large chorionic villi
Kernicterus ( > 20 mg/dl )
HYDROPS FETALIS
AR
Mutations of gene: phenylalanine hydroxylase
Inability to convert phenylalanine to tyrosine
Musty or mousy odor to affected infants
Brain damage and mental retardation
PHENYLKETONURIA
Most common variant of Galactosemia?
Galactose-1-phosphate uridyl transferase
Hepatomegaly Cataract due to sorbitol accumulation Failure to thrive Mental ratardation E. Coli septimecia
GALACTOSEMIA
AR
Loss of CFTR causes decreased Na and Cl reabsorption in sweat glands
Deletion of three nucleotides coding for phenylalanine at AMINO ACID POSITION 508
CYSTIC FIBROSIS
Most common lethal genetic disease that affect caucasian populations?
CYSTIC FIBROSIS
AR Infertility Meconium ileus ATROPHY of exocrine pancreas Respiratory infections due to P. AERUGINOSA
CYSTIC FIBROSIS
Most common cause of death of an infant younger than 1 year old which occur between 2 and 4 months?
SUDDEN INFANT DEATH SYNDROME
Most common tumors of infancy?
HEMANGIOMAS
Most common teratomas of childhood?
SACROCOCCYGEAL TERATOMAS
Most common extracranial solid tumor of childhood?
NEUROBLASTOMA
Neuropil ( faintly eosinophilic fibrillary material)
HOMER-WRIGHT pseudorosettes
Blueberry muffin baby
NEUROBLASTOMA
Homer-wright rosette is associated with?
NEUROBLASTOMA
MEDULLOBLASTOMA
PRIMITIVE NEUROECTODERMAL TUMORS
Flexner- Wintersteiner rosette is associated with?
RETINOBLASTOMA
Consist of tumor cells collected around a blood vessel
PERIVASCULAR PSEUDOROSETTE
Most common primary renal tumor of childhood?
WILMS TUMOR
2-5 years old Mutations in WT1 gene Involve both kidneys Triphasic combination Marked anaplasia
WILMS TUMOR
Interfers with normal remodeling of epiphyses in children (LEAD LINES) Ringed sideroblasts Microcytic hypochromic anemia Basophilic stippling Peripheral demyelinating neuropathy Saturnine gout
LEAD POISONING
What is the drug of choice for acute management of lead poisoning?
EDTA and DIMERCAPROL
What is the drug of choice for outpatient management of lead poisoning?
SUCCIMER
Cerebral palsy Deafness Blindness Mental retardation Dental amalgams
MERCURY POISONING/ MINAMATA DISEASE
Curling ulcers = ___________
Marjolin ulcers = ___________
Cushing ulcers = ___________
GASTRIC ULCER
SQUAMOUS CELL CARCINOMA
INCREASED INTRACRANIAL PRESSURE
What anesthetic drugs are implicated in malignant hyperthermia?
HALOTHANE SUCCINYLCHOLINE
What is the drug of choice for malignant hyperthermia?
DANTROLENE
Weight falls to 60% of normal Deficiency of all nutrients Growth retardation Loss of muscle Extremities are emaciated
MARASMUS
Malnutrition
Edema
Anemia
Liver (fatty)
KWASHIORKOR
Amenorrhea
Severe exercise
Severe diet
Psychiatric disorder
ANOREXIA NERVOSA
Sever dental carries Erosion of tooth enamel (perimolysis) Swollen salivary gland Calluses on back of hands (Russell's sign) Electrolyte imbalance
BULIMIA NERVOSA
Genu varum (bow legs) Rachitic rosary Bleeding gums Poor wound healing Perifollicular hemorrhage
SCURVY/ vitamin c deficiency
Craniotabes
Rachitic rosary
Pectus carinatum
Genu varum
RICKETS
What potentially fatal neurologic complication of measles is prevented by vaccination?
SUBACUTE SCLEROSING PANENCEPHALITIS
Rash on the face down to the proximal extremities
Whitish ulcerated oral mucosa lesions near the opening of stensen duct (kopliks spot)
WARTHIN-FINKELDEY CELLS
MEASLES
Parotitis
Orchitis
Pancreatitis
Encephalitis
MUMPS
WARTHIN-FINKELDEY CELLS
MUMPS
COWDRY TYPE A BODIES ( large, pink to purple intracellular inclusion)
HERPES SIMPLEX INFECTION
Dorsal root ganglion cell necrosis
Dew drop on a rose petal appearance of rash
RAMSAY HUNT SYNDROME
VARICELLA
OWL’S EYE INCLUSION (intracellular basophilic inclusions surrounded by halo)
CYTOMEGALOVIRUS
Blueberry muffin baby
Heterophil negative
Owl’s eye inclusion
CYTOMEGALOVIRUS
Drug of choice for CMV infection?
GANCICLOVIR
Positive heterophil antibodies
Splenic rupture
DOWNEY CELLS (B lymphocytes)
EPSTEIN-BARR VIRUS INFECTION
What malignancies are associated with EBV?
BURKITT’S LYMPHOMA
NASOPHARYNGEAL CANCER
Most common cause of mastitis?
STAPHYLOCCOCUS AUREUS
Erthryogenic toxin Strawberry tongue Centrifugal rash ( sandpaper like ) Pastia's line DICK TEST for susceptibility
SCARLET FEVER
Erysipelas, Pharyngitis and Scarlet fever is associated with etiologic agent?
STREPTOCOCCUS PYOGENES/ GABHS
Pseudomembrane
Myocarditis
Poyneuritis
Airway obstruction
CORYNEBACTERIUM DIPTHERIAE INFECTION
Gram positive intracellular bacilli in the CSF
Focal abscess
TUMBLING MOTILITY
LISTERIA MONOCYTOGENES
Swarming motility
PROTEUS SPP.
Shooting star motility
VIBRIO CHOLERA
Falling leaf motility
GIARDIA LAMBLIA
Mediastinal hemorrhage
Necrosis and exudative inflammation
BOXCAR SHAPED gram positive organism
BACILLUS ANTHRACIS
Beaded gram positive organism in branching filaments
Modified acid fast stain (Fite Faraco)
Suppurative response with central liquefaction
No GRANULOMAS
NOCARDIA ASTEROIDES
Which virulence factor causes whooping in pertussis infection?
TRACHEAL CYTOTOXIN
Necrotizing pneumonia Well demarcated necrotic and hemorrhagic oval skin lesions (Ecthyma gangrenosum) Fleur de lis pattern Hot tub vasiculitis Malignant otitis externa
PSEUDOMONAS AERUGINOSA INFECTION
Painful genital ulcer (CHANCROID)
HAEMOPHILUS DUCREYI
Beefy red ulcer Pseudoepitheliomatous hyperplasia DONOVAN BODIES ( encapsulated cocobacilli in macrophages)
KLEBSIELLA GRANULOMATIS INFECTION
Granuloma formation with caseation necrosis
Potts disease
Lymphadenitis
Used of carbol fucshin for primary stain in the identification of the bacteria
MYCOBACTERIUM TUBERCULOSIS
Most frequent presentation of extrapulmonary TB?
Scrofula in cervical region
LYMPHADENITIS
Most common site of intestinal tuberculosis?
ILEUM
Abundant acid fast bacilli with macrophage associated with AIDS patients with CD4 < 50
MYCOBACTERIUM AVIUM
Hypopigmented plaques
Painless lesion
Bacilli are almost never found
Paucibacillary
TUBERCULOID LEPROSY
LIPID LADEN MACROPHAGES
Globi
Ulnar and peroneal nerves
Sterility
LEPROMATOUS LEPROSY
Palmar rash Chancre Condyloma latum Gummas Neurosyphillis
SYPHILLIS/ TREPONEMA PALLIDUM
Bullos eruption with epidermal sloughing Osteochondritis and periostitis Pale and airless lungs (pneumonia alba) Hutchenson teeth Diffuse hepatic fibrosis
CONGENITAL SYPHILLIS
Macrophage with red cells
Moderate splenomegaly
Acrodermatitis atrophicans
BORRELIA RECURRENTIS
Erythema chronicum migrans
Lyme arthritis
Lyme miningitis
BORRELIA BURGDOFERI