Musculoskeletal

Question 1

What defects exist with Leukocyte Adhesion Disorder (LAD)?

Answer 1

1. Deficiency results from autosomal recessive genetic absence of CD18.
2. Inability to synthesize Integrins: needed for leukocytes to exit the blood stream.
3. Causes:
   - recurrent infections WITHOUT pus formation
   - Delayed detachment of umbilical cord
   - Poor wound healing