Muscular System Flashcards

1
Q

Functions of muscle three tissue types?

A
  • Smooth muscle- Moving food through the digestive tract, emptying the uniary bladder, regulating blood vessel diameter, changing pupil size, contracting many gland ducts. moving hair.
  • Skeletal muscle-Body movement
  • Cardiac muscle- Pumping blood; contractions provide the major force propelling blood through blood vessels.
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2
Q

Smooth muscle

A

The most widely distributed type of muscle in the body. Found in the walls of hollow organs (stomach, uterus, tubes; blood vessels, ducts of certain glands, and iris for pupil dilation). They propel urine through the urinary tract, mixing food in the stomach and small intestine, dilating and contracting the pupil of the eye, and regulating the flow of blood through blood vessels.
pg 269

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3
Q

Cardiac muscle

A

Found only in the heart, and its contractions provide the major force for moving blood through the circulatory system. Can contract spontaneously and rhythmically. This property is autorhythmicity; nervous or hormonal stimulation is not always required for them to contract. They are controlled involuntarily., by autonomic nervous and endocrine systems
pg 269

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4
Q

Major functions of all three types of muscles

A
  1. Movement of the body- Most skeletal muscles are attached to boned and are responsible for the majority of body movements, including walking, running, chewing, and manipulating objects with the hands.
  2. Maintenance of posture- Skeletal muscles constantly maintain tone, which keeps us sitting or standing erect.
  3. Respiration-Skeletal muscles of the thorax carry out breathing movements.
  4. Production of body heat- When skeletal muscle contract, heat is given off as a by-product. This released heat is critical for maintaining body temperature.
  5. Communication- Skeletal muscles are involved in all aspects of communication, including speaking, writing, typing, gesturing, and smiling or frowning.
  6. Constriction of organs and vessels- The constriction of smooth muscle within the walls of internal organs and vessels causes those structures to constrict. This constriction can propel mixe food and water in the digestive tract; remove materials from organs, such as the urinary bladder or sweat glands; and regulate blood flow through vessels.
  7. Contraction of the heart- The contraction of cardiac muscle causes the heart to beat, propelling blood to all parts of the body.
    pg 269-270
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5
Q

Excitability

A

The capacity of muscle to respond to an electrical stimulus. Normally, the stimulus is from nerves that we consciously control. Smooth and cardiac muscle also respond to stimulation by nerves and hormones but can sometimes contract spontaneously.
pg 270

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6
Q

Extensibility

A

A muscle can be stretched beyond its normal resting length and still be able to contract.
pg 270

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7
Q

Where are skeletal muscle found?

A

Attached to bones

pg 269

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8
Q

Where are smooth muscle found?

A

Walls of hollow organs, blood vessels, eyes, glands, and skin
pg 269

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9
Q

Where are cardiac muscle found?

A

Heart

pg 269

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10
Q

Fasciculus

A

A muscle is composed of numerous visible bundles

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11
Q

What is Epimysium?

A

The entire muscle is surrounded by a layer of dense irregular collagenous connective tissue
pg 270

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12
Q

What is Perimysium

A

Each fasciculus is surrounded by a connective tissue layer

pg 270

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13
Q

Fasciculus

A

A muscle is composed of numerous visible bundles

pg 270

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14
Q

Epimysium

A

The entire muscle is surrounded by a layer of dense irregular collagenous connective tissue
pg 270

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15
Q

Perimysium

A

Each fasciculus is surrounded by a connective tissue layer

pg 270

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16
Q

Endomysium

A

Second layer that consists of reticular fibers, but is much thicker
pg 272

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17
Q

Muscle fiber

A

Develop from less mature, multinucleated cells called myoblasts. The mutiple nuclei found skeletal muscle fibers result from the fusion of myoblast precursor cells, not from the division of nuclei within myoblasts. Muscle fibers differentiate into functional muscle fibers as contractile proteins accumulate within their cytoplasm. Shortly after the myoblasts form, nerve begins to innervate the developing muscle fibers.
pg 272

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18
Q

Myofilament

A

Actin filaments (thin myofilaments) are about 8 nanometers in diameter and 1000 nm in length.

Myosin myofilaments (thick myofilaments) are about 12 nm in diameter and 1800 nm in length.

They are arranged in a highly ordered units called sarcomeres, which join end to end to form the myofibrils.

The arrangments actin and myosin myofilaments gives myofibrils its banded/striated look.
pg 272

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19
Q

Myofibril

A

Sacroplasm contains numerous bundles of myofibrils. Each one a threadlike structure, about 1-3 um in diameter, that extends the length of the muscle fiber. Contains two kinds of protein filaments, called myofilament. Actin and myosin myofilaments
pg 272

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20
Q

bnm,

A

*Actin filaments- small fibrils, an=bout 8nm in diameter, that form bundles, sheets or networks in the cytoplasm. Provide structure to the cytoplasm and mechanical support for microvilli. Actin filaments also support the plasma membrane and define the shape of the cell. Changes in shape involve breakdown and reconstruction of actin filaments. These changes in shape allow some cells to move about. Responsible for muscle contractile capabilities.

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21
Q

Muscle fiber structure

A

The plasma membrane of the muscle fiber is called a sarcolemma.

Two delicate connective tissue layers are located just outside the sarcolemma. The deeper and thinner of the two is the external lamina. Consist mostly of reticular (collagen) fibers. The second layer also consists of reticular fibers but is a much thicker layer, called endomysium.

Along the surface of the sarcolemma are many tublike invaginations of the sarcolemma, called transverse tubules, or T tubules. They occur regular intervals along the muscle fiber and extend inward, connecting the extracellular environment with the interior of the muscle fiber.

The T tubules lie adjacent to the highly organized smooth endoplasmic reticulum, called sarcoplasmic reticulum, in skeletal muscle fibers.

Other organelles, such as mitochondria and energy storing glycogen granules, are packed into the cell and constitute the cytoplasm, which in muscle fibers is known as the sarcoplasm.

Sarcoplasm also contains numerous bundles of protein filaments called myofibrils. A myofibril contains both actin and myosin and myosin myofilaments.

The two myofilament are arranged into sarcomeres

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22
Q

Muscle fiber structure

A

The plasma membrane of the muscle fiber is called a sarcolemma.

Two delicate connective tissue layers are located just outside the sarcolemma. The deeper and thinner of the two is the external lamina. Consist mostly of reticular (collagen) fibers. The second layer also consists of reticular fibers but is a much thicker layer, called endomysium.

Along the surface of the sarcolemma are many tublike invaginations of the sarcolemma, called transverse tubules, or T tubules. They occur regular intervals along the muscle fiber and extend inward, connecting the extracellular environment with the interior of the muscle fiber.

The T tubules lie adjacent to the highly organized smooth endoplasmic reticulum, called sarcoplasmic reticulum, in skeletal muscle fibers.

Other organelles, such as mitochondria and energy storing glycogen granules, are packed into the cell and constitute the cytoplasm, which in muscle fibers is known as the sarcoplasm.

Sarcoplasm also contains numerous bundles of protein filaments called myofibrils. A myofibril contains both actin and myosin and myosin myofilaments.

The two myofilament are arranged into sarcomeres
pg 272

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23
Q

Thick filament

A

Myosin

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24
Q

Z-disc

A

Separates one sarcomere from the next. It is a filamentous network of protein that forms a stationary anchor for the attachment of actin myofilaments.

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25
Q

Z-disc

A

Separates one sarcomere from the next. It is a filamentous network of protein that forms a stationary anchor for the attachment of actin myofilaments.
pg 273

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26
Q

Regions of the sarcomere

A

The basic structural and functional unit of skeletal muscle because it is the smallest portion of a skeletal muscle capable of contracting. Each one extends from one Z disk to the next Z disk.

Each sarcomere consists of two light-staining bands are called isotropic bands, I bands, Each I band includes a Z disk and extends to the end of the myosin filaments.

The dark-staining band at the center of each sarcomere is an anisotropic band or A band. Each A band extends the length of the myosin myofilaments within a sarcomere.

In the center of each A band is a smaller band called H zone, where actin and myosin myofilaments DO NOT overlap and only myosin myofilaments are present.

A dark line, called M line, is in the middle of the H zone and consists of delicate filaments that attache to the center of the of the myosin filaments.
pg 273

27
Q

M- line

A

A dark line, called M line, is in the middle of the H zone and consists of delicate filaments that attache to the center of the of the myosin filaments.
pg 273

28
Q

Titin

A

One of the largest known proteins, consisting of a single chain of nearly 27,000 amino acids. Attaches to Z disks and extends along myosin myofilaments to the M line. The myosin myofilaments are attached to the titin molecules, which help hold the position. Part of the titin molecules in the I band functions as a spring, allowing the sarcomere to stretch and recoil.
pg 274

29
Q

Troponin and Tropomyosin

A

Each actin myofilament consists of fibrous actin, a series of tropomyosin molecules, and a series of troponin molecules.

Tropomyosin is an elongated protein that winds along the groove of F actin double helix. Each one is sufficient to cover seven G actin active sites.

Troponin is omposed of three subunits; one binds to actin; a second that binds to tropomyosin; and a third that has a binding site for Ca2+.
pg 275

30
Q

Cross-bridge

A

Myosin heads cand bind to active sites on the actin molecules to form cross bridges.

The globular head of a myosin molecule that projects from a myosin filament in muscle and in the sliding filament hypothesis of muscle contraction is held to attach temporarily to an adjacent actin filament and draw it into the A band of a sarcomere between the myosin filaments
pg 275

31
Q

Myosin head parts

A
  1. The heads can bind to active sites on the actin molecules to form cross-bridges.
  2. The heads are attached to the rod portion by a hinge region that can bend and straighten during contraction
  3. The heads are ATPase enzymes, which break down adenosine triphosphate (ATP), releasing energy. Part of the energy used to bend the hinge of the myosin molecule during contraction.
32
Q

Sarcomere

A

The basic structural and functional unit of skeletal muscle because it is the smallest portion of a skeletal muscle capable of contracting. Each one extends from one Z disk to the next Z disk.

33
Q

Sarcoplasm

A

Other organelles, such as mitochondria and energy storing glycogen granules, are packed into the cell and constitute the cytoplasm, which in muscle fibers is known as the sarcoplasm.

Sarcoplasm also contains numerous bundles of protein filaments called myofibrils. A myofibril contains both actin and myosin and myosin myofilaments.

34
Q

Sarcolemma

A

The plasma membrane of the muscle fiber is called a sarcolemma.

35
Q

Movement of actin and myosin in contraction
and
Sliding Filament Model

A

The primary function skeletal muscle cells is to generate force by contracting or shortening. The parallel arrangement of myofilaments in a sarcomere allows them to interact, which causes muscle contraction. This is the Sliding Filament Theory

when a muscle contracts, the actin and myosin myofilaments in the sarcomere slide past one another but remain the same length as when the muscle is a rest. When the myofilaments slide past each other and the sarcomere shortens, the myofibrils also shorten because the myofibrils consist of sarcomeres joined end to end.

The myofibrils extend the length of the muscle fibers, and when they shorten the muscle fibers shorten.

When sarcomeres shorten, myofibrils, muscle fibers, muscle fascicles, and muscles shorten to produce muscle contraction.
pg 276

36
Q

What causes an action potential to move?

A

pg 279

37
Q

Role of K, Na, and Ca

A

pg 278

38
Q

Voltage-gated ion channels

A

pg 280

39
Q

Ion Pump

A

pg 278

40
Q

Leakage channels

A

No idea. Figure it out.

41
Q

Depolarization

A

The depolarization phase of an action potential is a brief period during which further depolarization occurs and the inside of the of the cell becomes positively charged. pg 280

42
Q

Threshold of an action potential

A

Value of the membrane potential at which an action potential is produced as a result of depolarization in response to a stimulus.
pg 280

43
Q

All or none response

A

When a stimulus is applied to a cell, an action potential is either produced or not. In muscle cells, the cell either contracts to the maximum extent possible or does not contract.
pg 280

44
Q

Repolarization

A

The return of the membrane potential to its resting value.

45
Q

Neuromusclar Junctions

A

pg 282

46
Q

Postsynaptic membrane

A

NI

47
Q

Neurotransmitter

A

ss

48
Q

Presynaptic terminal

A

z

49
Q

Synaptic cleft

A

a

50
Q

Receptors

A

x

51
Q

t-tubules

A

a

52
Q

Ligand-gated sodium channels

A

s

53
Q

Sarcoplasmic reticulum

A

x

54
Q

Step in the neuromuscular junction

A

x

55
Q

Steps in excitation-contraction

A

a

56
Q

Power stroke

A

Movement of the myosin molecule while the cross-bridge is called the power stroke, whereas return of the myosin head to its original position after cross-bridge releases is called recovery stroke.
pg 287

57
Q

Steps of relaxation

A

pg 287

58
Q

Graded contraction of whole muscle

A

a

59
Q

tetanus

A

As the frequency of action potentials in a skeletal muscle fiber increases, the frequency of contraction also increases until a period of sustained contraction, or tetanus is achieved.
pg 290

60
Q

Acetylcholinesterase

A

d

61
Q

What connection do muscles have to CNS

A

s

62
Q

Names of the cell that makes muscle cells

A

s

63
Q

Morphology of each of the three types

A

s