Muscle Spasm and Spasticity

Question 1

Baclofen - use

Answer 1

spasticity in MS and some spinal cord injury

doesn’t decrease muscle strength

Question 2

Baclofen - AE

Answer 2

drowsiness, dizziness, weakness and fatigue
N/V, constipation, and urinary retention (low risk)
can exacerbate psych
- overdose - resp depression
- withdraw slowly

Question 3

Baclofen - contraindications

Answer 3

• alcohol and CMS depressants

- h/o urinary retentions, BPH, or taking a drug that causes urinary retention

Question 4

diazepam (valium) - use and class

Answer 4

benzodiazepine

GAD, seizures, muscle spasm and spasticity, Alcohol withdraw, and preanesthetic

Question 5

diazepam (valium) - AE

Answer 5

sedation

Question 6

dantrolene - use

Answer 6

acts on skeletal muscle
spasticity associated with MS, CP, and spinal cord injury
- may see decrease in strength
- if no benefits in 45 days, d/c

Question 7

dantrolene - AE

Answer 7

hepatic toxicity -most common in women > 35 BBW

muscle weakness, drowsiness, diarrhea, N/V, dysphagia, hoarseness, and ED

Question 8

cyclobenzaprine - uses

Answer 8

1st choice for muscle spasm r/t epilepsy, hypocalcemia, and injury

Question 9

cyclobenzaprine - AE

Answer 9

CNS depressants (decrease with continued use), anticholinergic effects, cardiac dysrhythmias

Question 10

cyclobenzaprine - contrindications

Answer 10

MOA inhibitors SSRI and SNRI, pts with cardiac rhythm abnormalities

Question 11

Valium - contraindication

Answer 11

glaucoma, respiratory or liver impairment, OSA, and Myasthenia gravis

Question 12

Metaxalone - contraindications

Answer 12

impaired hepatic or renal impairment, h/o anemia, increases r/o serotonin syndrome in patients taking SSRI’s

Question 13

methocarbamol - contraindications

Answer 13

avoid in patient with seizures or renal impairment; hepatic impairment

Question 14

orphenadrine - contraindications

Answer 14

glaucoma, myasthenia gravis, GI obstruction, bladder obstruction, heart disease or failure