muscle relaxants Flashcards

1
Q

cyclobenzaprine brands

A

Flexeril

Amrix

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2
Q

flexeril
amrix
generic

A

cyclobenzaprine

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3
Q

cyclobenzaprine MOA

A

skeletal muscle relaxant (antispasmodic)

  • works at brainstem level
  • anticholinergic activity
  • potentiates NE
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4
Q

how is flexeril cyclobenzaprine cleared?

A

renal drug

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5
Q

t/f flexeril effective in spasticity due to spinal cord or cerebral injury, cerebral palsy, ?

A

no not effective

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6
Q

cyclobenzaprine ADR

A
  • think anticholinergic effects
  • dry mouth
    HA
    somnolence
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7
Q

flexeril, amrix drug interactions

A
  • MAOI: fatal interaction
  • ETOH other depressants
  • increase risk sz with tramadol!!
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8
Q

warnings cyclobenzaprine

A
  • urinary retention

- increases IOP (acute angle closure glaucoma)

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9
Q

who concerned increased IOP with cyclobenzaprine

A

those at risk for acute angle closure glaucoma

  • farsighted hyperopes
  • women
  • asian
  • older
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10
Q

carisoprodol (Soma) is a muscle relaxant however don’t rx because

A

high abuse potential
MOA not fully understood

rare ADR: transient quadriplegia

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11
Q

metaxalone (skelaxin) MOA

A

not well known

  • CNS depression
  • no direct muscle effect
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12
Q

metaxalone ADR

A

N/V GI upset
leukopenia
hemolytic anemia
jaundice

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13
Q

methocarbamol brand

A

robaxin

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14
Q

baclofen brands

A

kemstro, lioresal, gablofen

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15
Q

baclofen MOA

A

GABA analog

inhibits reflexes at spinal level

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16
Q

___ is indicated for spasms due to multiple sclerosis, trigeminal neuralgia, spinal cord injury

A

baclofen (kemstro, gablofen, lioresal)

17
Q

baclofen potential helps ___

A

treat addiction

  • opioid
  • cocaine
  • ETOH
18
Q

orphenadrine brand

A

norflex

norgesic

19
Q

orphenadrine moA

A

analgesic
anticholinergic
(ADR: blurr vision, mydriasis, increased weakness, N/V etc)

20
Q

chlorzoxazone brands

A

parafon forte

lorzone

21
Q

chlorzoxazone MOA

A

inhibits multisynaptic reflex arcs that produce spasms

  • relieves pain, increase mobility
22
Q

chlorzoxZONE VS ORPHENADRINE

A

chlorzoxazone is less anticholinergic

better well tolerated

23
Q

what lab get prior to start on chlorzoxazone

A

LFT

can cause idiosyncratic hepatotoxicity

24
Q

what is glucosamine sulfate

A

works well with horse RA

-

25
MOA glucosamine sulfate
amino sugar that is part of cartilage proteoglycans, found in tendons, cartilage, ligaments, synovial fluid etc - stimulates metabolism of chondrycytes in articular cartilage - improves pain and function
26
what warning with glucosamine hydrochloride
make sure pt does not have shellfish allergy as it comes from seashells
27
topical methyl salicylate (wintergreen oil) topical pain relief worry about
ASA allergy watch with anticoagulants short term use no longer than 1 week
28
how does topical capsaicin work
- counter irritant | - creates local irritation/ inflammation to relieve inflammation in underlying or adjacent tissues
29
menthol is active ingredient in
peppermint
30
menthol uses
- orally for GI complaints - antispasmodic for IBS - relaxes LES - lower GI motility - topically for pain ADR: heartburn, N/V, contact dermatitis
31
menthol rub abuse
- applying to eye | - huffing vicks vapor rub etc
32
camphor is what
topical antitussive / analgesic - can cause resp failure, sz
33
post-herpetic neuralgia topical recommended
capsaicin | - stimulates TRPV1 which stimulates pain receptors and brings relief to area depletes substance P