muscle relaxants

Question 1

cyclobenzaprine brands

Answer 1

Flexeril

Amrix

Question 2

flexeril
amrix
generic

Answer 2

cyclobenzaprine

Question 3

cyclobenzaprine MOA

Answer 3

skeletal muscle relaxant (antispasmodic)

• works at brainstem level
• anticholinergic activity
• potentiates NE

Question 4

how is flexeril cyclobenzaprine cleared?

Answer 4

renal drug

Question 5

t/f flexeril effective in spasticity due to spinal cord or cerebral injury, cerebral palsy, ?

Answer 5

no not effective

Question 6

cyclobenzaprine ADR

Answer 6

• think anticholinergic effects
• dry mouth
  HA
  somnolence

Question 7

flexeril, amrix drug interactions

Answer 7

• MAOI: fatal interaction
• ETOH other depressants
• increase risk sz with tramadol!!

Question 8

warnings cyclobenzaprine

Answer 8

• urinary retention

- increases IOP (acute angle closure glaucoma)

Question 9

who concerned increased IOP with cyclobenzaprine

Answer 9

those at risk for acute angle closure glaucoma

• farsighted hyperopes
• women
• asian
• older

Question 10

carisoprodol (Soma) is a muscle relaxant however don’t rx because

Answer 10

high abuse potential
MOA not fully understood

rare ADR: transient quadriplegia

Question 11

metaxalone (skelaxin) MOA

Answer 11

not well known

• CNS depression
• no direct muscle effect

Question 12

metaxalone ADR

Answer 12

N/V GI upset
leukopenia
hemolytic anemia
jaundice

Question 13

methocarbamol brand

Answer 13

robaxin

Question 14

baclofen brands

Answer 14

kemstro, lioresal, gablofen

Question 15

baclofen MOA

Answer 15

GABA analog

inhibits reflexes at spinal level

Question 16

___ is indicated for spasms due to multiple sclerosis, trigeminal neuralgia, spinal cord injury

Answer 16

baclofen (kemstro, gablofen, lioresal)

Question 17

baclofen potential helps ___

Answer 17

treat addiction

• opioid
• cocaine
• ETOH

Question 18

orphenadrine brand

Answer 18

norflex

norgesic

Question 19

orphenadrine moA

Answer 19

analgesic
anticholinergic
(ADR: blurr vision, mydriasis, increased weakness, N/V etc)

Question 20

chlorzoxazone brands

Answer 20

parafon forte

lorzone

Question 21

chlorzoxazone MOA

Answer 21

inhibits multisynaptic reflex arcs that produce spasms

• relieves pain, increase mobility

Question 22

chlorzoxZONE VS ORPHENADRINE

Answer 22

chlorzoxazone is less anticholinergic

better well tolerated

Question 23

what lab get prior to start on chlorzoxazone

Answer 23

LFT

can cause idiosyncratic hepatotoxicity

Question 24

what is glucosamine sulfate

Answer 24

works well with horse RA

-

Question 25

MOA glucosamine sulfate

Answer 25

amino sugar that is part of cartilage proteoglycans, found in tendons, cartilage, ligaments, synovial fluid etc

• stimulates metabolism of chondrycytes in articular cartilage
• improves pain and function

Question 26

what warning with glucosamine hydrochloride

Answer 26

make sure pt does not have shellfish allergy as it comes from seashells

Question 27

topical methyl salicylate (wintergreen oil) topical pain relief worry about

Answer 27

ASA allergy
watch with anticoagulants
short term use no longer than 1 week

Question 28

how does topical capsaicin work

Answer 28

• counter irritant

- creates local irritation/ inflammation to relieve inflammation in underlying or adjacent tissues

Question 29

menthol is active ingredient in

Answer 29

peppermint

Question 30

menthol uses

Answer 30

• orally for GI complaints
• antispasmodic for IBS
• relaxes LES
• lower GI motility
• topically for pain

ADR: heartburn, N/V, contact dermatitis

Question 31

menthol rub abuse

Answer 31

• applying to eye

- huffing vicks vapor rub etc

Question 32

camphor is what

Answer 32

topical antitussive / analgesic

• can cause resp failure, sz

Question 33

post-herpetic neuralgia topical recommended

Answer 33

capsaicin

- stimulates TRPV1 which stimulates pain receptors and brings relief to area depletes substance P