Muscle relaxants

Question 1

Function of BOTOX

Answer 1

Irreversibly blocks acetylcholine release from presynaptic motor neuron terminals

Used for

• Ocular spasms
• Esophageal spasms
• Vocal cord spasms

Question 2

Function of Dantrolene

Answer 2

Dantrolene decreases Ca2+ release from the sarcoplasmic reticulum to inhibit coupling.

We use it for malignant hyperthermia.

Question 3

What is malignant hyperthermia?

Answer 3

Potentially life threatening muscle rigidity that leads to hyperthermia, increased muscle metabolism, metabolic acidosis and tachycardia