Muscle Disease Flashcards
What is the difference between polymyositis and dermatomyositis?
Dermatomyositis = polymyositis + skin changes
The risk of malignancy increases with polymyositis and dermatomyositis. True/False?
True
List the classic presenting MSK features of poly/dermato -myositis
Muscle weakness that worsens over months
Symmetrically affected
Myalgia
Difficulty with daily tasks
List investigations for poly/dermato -myositis
Inflammatory markers Muscle enzyme (CK) Autoantibodies Electrolytes Electromyography
Which antibodies are associated with poly/dermato -myositis?
ANA
Anti-Jo-1
What is the definitive test for poly/dermato -myositis?
Muscle biopsy
List the main treatment for poly/dermato -myositis
Steroids
Immunosuppression (methotrexate, azathioprine)
Ciclosporin
Rituximab
What is the steroid usually used for poly/dermato -myositis?
Prednisolone 40mg daily
Inclusion body myositis is more common in males. True/False?
True
Is muscle weakness in inclusion body myositis usually symmetrical or asymmetrical?
Asymmetrical
CK levels in inclusion body myositis are increased to a lesser fold compared to poly/dermato -myositis. True/False?
True
Inclusion body myositis is associated with anti-Jo-1 antibody. True/False?
False
Polymyalgia rheumatica is associated with which arteritic disease?
Giant cell arteritis
Muscle weakness if a feature of polymyalgia rheumatica. True/False?
False
List the common features of polymyalgia rheumatica
Morning stiffness - can’t get out of bed
Fatigue
Anorexia
Reduced movement
What is the mainstay of treatment for polymyalgia rheumatica?
Low dose steroid - usually rapid/dramatic response
What is the commonest cause of chronic MSK pain?
Fibromyalgia
Is fibromyalgia inflammatory?
No
Fibromyalgia is commoner in which sex?
Women
List some clinical features of fibromyalgia
Broken sleep Pain all over body Pins and needles Headaches Depression Tenderness on soft tissues
