Muscle And NMJ

Question 1

Gene that confers risk of statin myopathy

Answer 1

SLCO1B1
Codes for an organic anion-transporting polypeptide
If hetero 4.5x
If homo 17x

Question 2

Statins more frequently associated with myopathy

Answer 2

Newer synthetic ones:
Atorvastatin
Fluvastatin
Cerivastatin

Question 3

Which of these agents that may cause myathenic weakness is paired wrongly with its mechanism?
A. Botulinum - binds to cholinergic motor endings, blocking quantal release of ACh
B. Black widow spider venom - massive release of ACh resulting in ms contraction then paralysis from lack of ACh
C. d-tubocurarine - binds to AChR
D. Suxamethonium, decamethonium - binds to AChR
E. Organophosphates - binds irreversibly to AChR
F. Malathion and Parathion - inhibit AChE

Answer 3

E. Organophosphates bind irreversibly to AChE blocking hydrolysis of ACh.
Rest are properly matched