Muscarinic Antagonists

Question 1

Atropine, homatropine, tropicamide

target and clinical use

Answer 1

Eye

Produce mydriasis and cycloplegia

Question 2

Benztropine

target and clinical use

Answer 2

CNS

Parkinson Disease and Acute Dystonia

Question 3

Glycopyrrolate (parenteral and oral)

target and clinical use

Answer 3

GI, Respiratory
Parenteral: preoperative use to reduce airway secretions.
Oral: drooling, peptic ulcer.

Question 4

Hyoscyamine, dicyclomine

target and clinical use

Answer 4

GI

Antispasmodics for IBS

Question 5

Ipratropium, tiotropium

target and clinical use

Answer 5

Respiratory

COPD, Asthma

Question 6

Oxybutynin, solifenacin, tolterodine

target and clinical use

Answer 6

Genitourinary

Reduce bladder spasms and urge urinary incontinence (overactive bladder)

Question 7

Scopolamine

target and clinical use

Answer 7

CNS

Motion Sickness

Question 8

Atropine clinical use

Answer 8

Used to treat bradycardia and for ophthalmic applications.

Question 9

Atropine Toxicity

Answer 9

increase body temperature (due to decreased sweating)

rapid pulse; dry mouth; dry, ushed skin; cycloplegia; constipation; disorientation

Can cause acute angle-closure glaucoma in elderly (due to mydriasis), urinary retention in men with prostatic hyperplasia, and hyperthermia in infants