Murphy Drug Action

Question 1

Pharmacokinetics vs. Pharmacodynamics

Answer 1

Pharmacokinetics - what the body does to drugs

Pharmacodynamics - what drugs do to the body

Question 2

FDA approved ACE inhibitors for hypertension

Answer 2

Benazopril (Lotensin)
Captopril (Capoten)
Enalapril/Enalaprilat (Vasotec)
Fosinopril (Monopril)
Lisinopril (Zestril and Prinivil)
Moexipril (Univasc)
Perindopril (Aceon)
Quinapril (Accupril)
Ramipril (Altace)
Trandolapril (Mavik)

Question 3

Drug Response

Answer 3

f (Drug Efficacy)

Question 4

Drug Dose or Concentration

Answer 4

f (1/Drug Potency)

Question 5

Efficacy vs. Potency

Answer 5

Efficacy is defined as the maximum effect a drug can produce, regardless of the dose (how big). Potency is related to the amount of drug needed to produce a given effect (how much); it is often quantified by the ED50 or EC50.

Question 6

ED50 or EC50

Answer 6

The drug dose or concentration that causes 50% of the maximum effect.

Question 7

Therapeutic Window

Answer 7

The range of drug concentrations providing therapeutic effect with minimal side effects. The higher the concentration past the therapeutic window increases the likelihood of adverse side effects.