Multiple Sclerosis Medications

Question 1

Interferon beta-1b

Answer 1

Brand: Betaseron
Monitoring: CBC, LFTs, TSH

Question 2

FDA approved medication for PPMS

Answer 2

Ocrelizumab (Ocrevus)

Question 3

FDA approved medication for SPMS

Answer 3

Siponimod (Mayzent)

Question 4

Alemtuzumab

Answer 4

Brand: Lemtrada
MOA: anti-CD52 MAB

Question 5

Ocrelizumab

Answer 5

Brand: Ocrevus
MOA: Anti-CD20 MAB
Pre-Initiation: hepatitis panel

Question 6

Dimethyl Fumarate

Answer 6

Brand: Tecfidera
MOA: Activation of NRF2 pathway (antioxidant)

Question 7

Fingolimod

Answer 7

Brand: Gilenya
MOA: Sphingosine 1-phosphate receptor modulator (sequestration of lymphocytes in lymph nodes)
Pre-Initiation: VZV antibodies
AE: Bradycardia

Question 8

Natalizumab

Answer 8

Brand: Tysabri
MOA: Alpha 4 integrin MAB (prevents T cell migration across BBB)
Pre-Initiation: JCV virus titer

Question 9

Siponimod

Answer 9

Brand: Mayzent
MOA: Sphingosine 1-phosphate receptor modulator (sequestration of lymphocytes in lymph nodes)
AE: Bradycardia

Question 10

Glatiramer Acetate

Answer 10

Brand: Copaxone
MOA: Switches TH1 T cells to TH2 T cells
AE: Lipoatrophy