Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology 2 > Multiple Sclerosis > Flashcards

Multiple Sclerosis Flashcards

1
Q

Is MS more common in male or females?

A

Females

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the average age of onset of MS?

A

Around 30 years of age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What type of immunity is Th1 and Th2 involved in?

A

Th1 - cell mediated immunity
Th2 - humoral mediated immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Are Th17 cells pro or anti inflammatory?

A

Pro-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is expressed on the cell surface of B cells from stem cell all the way to plasma cell?

A

CD52

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name some emergency treatment options for the treatment of MS.

A
  1. Control of precipitant (e.g. infection, fever)
  2. Steroids (i.v. or oral methylprednisolone)
  3. I.v. immunoglobulin
  4. Plasmapheresis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the first line treatment for spasticity?

A

Baclofen or Gabapentin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the second line treatment for spasticity?

A

Tizanidine or Dantrolene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the third line treatment for spasticity?

A

BDZs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What drug is used for fatigue in MS patients?

A

Amantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What drug is used for walking problems in MS patients?

A

fampridine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which interferon shows benefit in the management of MS?

A

IFN-beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which 4 amino acids are glatiramer made up of?

A

Alanine, lysine, glutamic acid, tyrosine (4 amino acids found in myelin basic protein)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which is alpha4beta1 integrin located?

A

On the surface of T lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which drug targets alpha4beta1?

A

Natalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which drug causes rapid and prolonged depletion of CD52+ cells?

A

Alemtuzumab

17
Q

Which drug is a monoclonal antibody directed at B-lymphocytes expressing high levels of CD20?

A

Ocrelizumab

18
Q

Name 3 agents that target nucleic acid metabolism?

A

Mitoxantrone, oral cladribine, oral teriflunomide

19
Q

Name a type II topoisomerase inhibitor?

A

Mitoxantrone

20
Q

Which drug mimics nucleoside adenosine thereby interfering with their ability to process DNA?

A

Oral cladribine

21
Q

Which drug blocks the enzyme dihydroorotate dehydrogenase?

A

Oral teriflunomide

22
Q

What is fingolimod activated by?

A

Sphingosine kinase 2

Pharmacology 2 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions