Multiple pregnancy Flashcards
Discuss twin pregnancies
-Incidence in spontaneously conceived twins (3)
-Overall incidence of twins (1)
-Number of twin pregnancies due to fertility treatment (1)
-Rate of rise of multiple pregnancies (2)
-Reasons why multiple pregnancies are more common (2)
- Incidence in spontaneous pregnancy
-1:90 for twins 1%
-1:10 000 triplets 0.01%
-1: 600 000 quads 0.001% - Overall incidence of twins
-1.3% in NZ - Number of with pregnancies due to fertility treatment
-14% - Rise in multiple pregnancies
-70% increase over last 30 years
-Spontaneous twins account for a third of overall rise - Reasons for multiple pregnancies
-Older age of mothers
-ART
Discuss multiple pregnancies
-What does zygosity mean
-What does chronicity mean
- Zygosity: Number of fertilised eggs that pregnancy develops from
- Chronicity: Number of chorionic membranes / number of placenta
Discuss dizygotic twins
-Incidence (1)
-Development (1)
-USS findings (4)
- Incidence - 70%
- Development
-Develop from two eggs and two sperm (non-identical) - USS findings
-Scan between 10-14 weeks
-Lambda sign
-2 separate placental masses
-Thick septal edge
-Different sexes
Discuss monozygotic twins
-Incidence of DCDA, MCDA, MCMA (3)
-Development of different types (4)
-USS findings (3)
- Incidence
-DCDA - 30%
-MCDA - 70%
-MCMA - 1%
-Conjoined - Development
DCDA - single egg and sperm - Splits day 1-3
MCDA - single egg and sperm splits day 4-8
MCMA - single egg and sperm Splits day 8-13
Conjoined - single egg and sperm splits day 13-15 - USS findings
-Single placental mass
-Thin septum <1.8mm
-A-A anastomoses
-T sign
Discuss maternal complications of multiple pregnancies (14)
-Miscarriage
-Hyperemesis
-Anaemia
-GDM 2 x risk
-Preterm birth - iatrogenic and spontaneous
-Hypertensive disease 4 x risk
-VTE
-APH - increased placental bed
-Polyhydramnios - TTTS
-Operative delivery
-PPH - larger placental bed, over distension
-PND
-Maternal mortality 2.5 x risk
-Obstetric cholestasis
Discuss fetal complications of multiple pregnancies (8 groups)
Increased mortality. Increases with increased number
-5:1000 singleton, 12/1000 twins, 31/1000 triplets
-Increased with monochronicity esp. 20-30 weeks
Chromosomal abnormalities
-DC - 2 x overall risk each fetus same risk as singleton
-MC - same risk as singleton but both twins affected
Structural abnormalities
-DC same risk as singleton so 2 x risk
-MC 2-3 times risk due to uneven distribution of inner cell mass
Fetal growth restriction 2-3 x risk. More common in MC
PPROM
PTB - 60% of twins born before 37/40. 9% before 32/40
Long term disability - 4-8 x increased risk of CP
Infant feeding difficulties
What are the monochorionic specific fetal risks (4)
-Cord entanglement
-Selective IUGR
-TTTS
-TAPS
-TRAP
Discuss aneuploidy screening in multiple pregnancies
-Which screening tools can be used for twins
-Which screening tools can be used for triplets
- Twin pregnancy can use MSS1, MSS2, NIPT
- Triplets can use MSS1 only
Discuss MSS1 in multiple pregnancies
-When should MSS1 be done
-Which multiple pregnancies is it validated for
-How are results given for DC and MZ
-What is the sensitivity and why is it impacted
- MSS1 do 11-13+6
- MSS1 can be used in all twin and triplet pregnancies
- Results
DC - gives a chance score for each twin
MC - gives an overall chance score for the pregnancy
For MC twins use average of NT as it can differ - Sensitivity
-Same as for singleton pregnancies.
-Sensitivity is reduced secondary to maternal serum biomarkers
Discuss NIPT for multiple pregnancies
-When should NIPT be done
-Which multiple pregnancies is it validated for
-Discuss sensitivity and specificity for MZ and DZ twins
-Discuss reasons for higher failure rate (4)
- When should NIPT be done - After 10 weeks
- Which multiple pregnancies is it validated for - twins only
- Sensitivity and specificity
-99% for both for MZ twins
-Slightly less sensitive in DZ twins - Reasons for higher failure rates in twins
-Failure rate in singletons 2% failure in twins 6%
-Low fetal fraction
-Maternal obesity
-Suboptimal sample collection
Discuss prenatal diagnosis
-What form of prenatal diagnosis should be used for DC twins and why
-What form of prenatal diagnostic test should be used for MZ twins and why
-What are the considerations for prenatal diagnostic testing
- What form of prenatal diagnosis for DC twins
-CVS (11+2 - 13+6)
-Can do KCL selective reduction and this is done better at early gestations - What form of prenatal diagnosis for MC twins
-Amniocentesis (15+)
-Can’t do KCL for selective reduction. Must do cord occlusion. Better done later - Considerations
-Puts whole pregnancy at risk even if only one twin affected
-KCL risk of loss of remaining twin = 15%
-Cord occlusion risk of loss of remaining twin 13%
Discuss the implications of death of one twin
-Impact in MCDA (5)
-Impact if DCDA (6)
- Impact to MCDA twins
-Risk of death of remaining twin - 40%
-PTB 70%
-Abnormal antenatal cranial imaging - 30%
-Abnormal postnatal cranial imaging - 40%
-Neurodevelopmental impairment - 30% - Impact to DCDA twins
-Risk of death of remaining twin - 15% (5-10%)
-PTB - 50%
-Abnormal antenatal cranial imaging - 15%
-Abnormal postnatal cranial imaging - 20%
-Neurodevelopmental impairment - 10%
-Increased risk of CP
Discuss management of DC twins where one has died
-Causes (6)
-Monitoring (5)
-Reasons for delivery (2)
-Postnatal management (2)
- Causes
-FGR - increased risk with discordance >30%
-PET
-Abruption, infection, anomalies, cord accidents - Monitoring
-Anti-D if RH negative
-Weekly CTG
-Fortnightly growth scans - Reasons for delivery
-Death of a DC twin is not a reason for delivery
-Deliver if there is a condition affecting pregnancy as a whole - PET/DIC/ chorio
-Delay delivery if possible till >34/40
-Give steroids and MGSO4 as necessary - Postnatal management
-4-6 week postnatal MRI
-Long term neurodevelopmental FU
Discuss management when one MC twin dies in utero
-Incidence
-Causes
-Impact to surviving twin
-Management
- Incidence
-Spontaneous demise in 1% of MC twins - Causes
-TTTS (50%), Selective FGR, Fetal anomalies, TRAP, cord entanglement - Impact to surviving twin
-Result in acute haemorrhage and anaemia in live twin
-Can result in fetal heart failure
-Can cause severe brain damage >25%
-If occurs before 24/40 then high risk of second twin demise but less risk of brain damage
-If occurs after 24/40 then less risk of second twin demise but increased risk of brain damage - Management
-Offer TOP if peri-viable
-MRI 4-6/52 post fetal demise to assess fetal brain injury +/- feticide if intracranial pathology
-Weekly USS with MCA-PSV
-Weekly CTG
-Aim delivery at 37/40
-No point delivering early as damage already done unless acute concern for live twin
Discuss management of DCDA twins
-Antenatal (8)
- Antenatal management
-Determine chronicity approx 14 weeks and do NT if desired
-Consider LDA if additional risk factors for PET/IUGR
-Aneuploidy screening MSS1/NIPT
-OGTT for GDM
-Monthly scans from 20/40
-Check FBC at 20 - 24 weeks and 28 weeks
-Manage FGR same as in singletons
-Fe and folic acid supplementation for maternal anaemia
-Educate around PTD and consider Cx length but no evidence for progresterone or Cerclage