Multiple myeloma Flashcards
1
Q
Flow cytometry in multiple myeloma
A
CD138, CD 19,CD 56
2
Q
Site of lytic bone lesions in MM
A
Skull , long bones- rare below elbow and knee
3
Q
Prognostic markers in MM
A
B2 microglobulin, albumin, LDH, CRP, Labelling index
Cytogenetics -bad->Chr 13 deletion,hypodiploidy, t(4:14),(14,16)
4
Q
Hematological causes of monoclonal band other than MM
A
MGUS, Waldenstroms, NHL, CLL, amyloid (AL)
5
Q
Non hematological causes of monoclonal band
A
Autoimmune, chronic infection, Hep C, neuropthies, immune dermopathies
6
Q
Monoclonal antibody in MM
A
Daratumumab (anti-CD38)
Elotuzumab(Anti-SLAMF7)
7
Q
Thalidomide side effects
A
Constipation,somnolence,thrombosis, painful neuropathy,skin rash
8
Q
MOA Bortezomib
A
Proteasome inhibitor -results in apoptosis
Carfilzomib -better, no neuropathy
