Multiple Myeloma

Question 1

Common findings on a blood smear of a patient with multiple myeloma

Answer 1

anemia

rouleaux

Question 2

Percent of plasma cells in bone marrow which loosely qualifies as multiple myeloma

Answer 2

20%

Question 3

Triad of symptoms of multiple myeloma

Answer 3

anemia, bone pain, renal failure

Question 4

This test is used to identity an M spike

Answer 4

serum protein electrophoresis

Question 5

These proteins may be found in urine/diagnostic of myeloma

Answer 5

Bence-jones

Question 6

Describe the formation of bone lesions found with monoclonal gammopathy.

Answer 6

an increase in osteoclast activity and decrease in osteoblast cells suppresed by increased plasma cells

Question 7

Treatement for myeloma

Answer 7

Chemo - Dexamethasone, Melphalan, Cyclophosamide
Autologous stem cell transplant
Maintanance drugs - thalidomide, lenalidomide, biphosphanates, EPO

Question 8

cells found in malignant bone marrow (multiple myeloma)

Answer 8

plasmablast (no B cells or IgA/G)