Multiple Endocrine Neoplasia Type 4 Flashcards
1
Q
How does MEN4 present clinically?
A
With the same features as MEN1.
2
Q
What is the cause of MEN4?
A
Loss-of-function mutation in the CDKN1B gene that codes for the cyclin-dependent kinase inhibitor 1B.
3
Q
Mode of inheritance?
A
Autosomal dominant.
4
Q
What tumors seen in MEN4 are not typically seen in MEN1?
A
- Renal angiomyolipomas
2. Papillary thyroid cancer
5
Q
How are patients investigated and treated?
A
As in MEN1.
