Multiple Endocrine Neoplasia (MEN)

Question 1

What gene mutation causes MEN1?

Answer 1

MEN1

Question 2

What gene mutation causes MEN2?

Answer 2

RET gene

Question 3

What does the MEN1 mutation do?

Answer 3

Causes decreased menin protein function resulting in MEN1

Question 4

What does the RET gene mutation do?

Answer 4

Increases receptor tyrosine kinase function resulting in MEN2

Question 5

What is the RET gene?

Answer 5

Proto-oncogene (normal function but mutated version causes cancer)

Question 6

What does MEN1 cause?

Answer 6

Parathyroid hyperplasia

Pituitary adenoma

Pancreatic tumours

‘Three Ps’

Question 7

What does MEN2A cause?

Answer 7

Phaeochromocytoma
Medullary thyroid carcinoma (mild)
Parathyroid hyperplasia

Question 8

What does MEN2B cause?

Answer 8

Phaeochromocytoma
Medullary thyroid carcinoma (aggressive)
Mucosal neuroma

Question 9

What MEN syndrome causes mild medullary thyroid carcinoma and which causes aggressive medullary thyroid carcinoma?

Answer 9

Mild - MEN2A

Aggressive - MEN2B

Question 10

What MEN syndrome is often treated with a prophylactic thyroidectomy?

Answer 10

MEN2B

Question 11

What MEN syndrome is associated with a Marfanoid body?

Answer 11

MEN2B