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Endocrinology > Multiple endocrine neoplasia > Flashcards

Multiple endocrine neoplasia Flashcards

1
Q

Inheritance?

A

Autosomal dominant disorder

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2
Q

How many types of MEN are there?

A

3:
MEN type 1
MEN type 2a
MEN type 2b

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3
Q

What is affected in MEN type 1?

A

3 P’s

  • Parathyroid (95%): hyperparathyroidism due to parathyroid hyperplasia
  • Pituitary (70%)
  • Pancreas (50%): e.g. insulinoma, gastrinoma (leading to recurrent peptic ulceration)

Also: adrenal and thyroid

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4
Q

What gene is responsible for MEN type 1?

A

MEN1 gene

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5
Q

How does MEN type 1 most commonly present?

A

With hypercalcaemia

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6
Q

What symptoms are in MEN type 2a?

A

Medullary thyroid cancer (70%)

2 P’s

  • Parathyroid (60%)
  • Phaeochromocytoma
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7
Q

What gene is responsible for MEN type 2a?

A

RET oncogene

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8
Q

What gene is responsible for MEN type 2b?

A

RET oncogene

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9
Q

What occurs in MEN type 2b?

A

Medullary thyroid cancer

1 P
Phaeochromocytoma

Marfanoid body habitus
Neuromas

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Endocrinology (8 decks)

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