Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

endocrine > Multiple Endocrine Neoplasia > Flashcards

Multiple Endocrine Neoplasia Flashcards

1
Q

what inheritance is MEN?

A

autsomal dominant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is MEN type I?

A

3 P’s
* Parathyroid (95%)
* Pituitary (70%)
* Pancreas (50%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is MEN type IIa?

A

MEDULLARY THYROID cancer (70%)

2 P’s
* Parathyroid (60%)
* Phaeochromocytoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is MEN type IIb?

A

MEDULLARY THYROID cancer

1 P’s
* Phaeochromocytoma

NEUROMAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what parathyroid pathology is seen in MEN I?

A

primary hyperparathyroidism –> HYPERCALCAEMIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what abnormalities can be seen in pituitary adenoma in MEN I?

A
  • prolactinoma
  • raised GH
  • raised ACTH
  • raised TSH
'lots of milk leads to giant kids!'
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what pancreatic pathology is seen in MEN I?

A
  • gastrinoma
  • insulinoma
  • glucagonoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is seen in gastrinoma?

A

recurrent peptic ulcers + abdo pain + vomiting

caused by raised gastrin –> raised HCl (increased acid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is seen in insulinomas?

A
  • hypoglycaemia
  • hyperinsulinaemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is seen in glucagonoma?

A

hyperglycaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the cause of MEN I?

A

MEN I gene mutation

located on chromosome 11

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

which type of MEN II is most common?

A

MEN IIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what type of thyroid cancer is seen in MEN IIa and b?

A

medullary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is phaeochromocytoma?

A

adrenal medullary tumour

arises from chromaffin cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

how does phaeochromocytoma?

A
  • perspiration
  • palpitation
  • pallor
  • pain (e.g. headache)
  • pressure = raised BP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what parathyroid pathology is seen in MEN IIa?

A

primary hyperparathyroidism –> HYPERCALCAEMIA

17
Q

how do multiple neuromas present?

A
  • muscoal neuromas (eyelid, lip, tongue)
  • intestinal ganglioneuromas
18
Q

what causes MEN II?

A

mutation of RET gene

located on chromosome 10

19
Q

how body type is typically seen in MEN IIb?

A

marfanoid body habitus

tall, slender, lanky

endocrine (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions