multiple endocrine neoplasia Flashcards
1
Q
how is men inherited?
A
autosomal dominant
2
Q
what is the most common presentation of MEN1?
A
Hypercalcaemia
3
Q
what are the 3 main areas affected by men1?
A
- parathyroid-> hyperparathyroidism
- pituitary-> prolactinoma, acromegaly due to GH producing adenoma
- pancreas-> insulinoma or gastrinoma, leading to peptic ulceration
4
Q
which gene is involved in MEN1?
A
MEN1 gene
5
Q
which genes are involved in MEN2a and B?
A
RET oncogene
6
Q
which MENs predispose to cancer, and which type of cancer?
A
MEN2a and MEN2b predispose to medullary thyroid cancer
7
Q
which conditions are associated with MEN2a?
A
- parathyroid
- phaeochromocytoma
8
Q
which conditions are associated with MEN2b?
A
- pheochromocytoma
patients also have a mafanoid body type and neuromas
