Multifactorial Disorders Flashcards
What is the lambda S statistical value?
Relative risk to a person who is in a family where another sybling has the condition compared to the risk in the population as a whole
What does polygenic mean?
A condition that is not mendelian, but is inherited to the extent that it is influenced by multiple genes - it is complex (environmental factors too) additive
Many human traits are inherited by what method?
Complex - may run in families but not obeying mendels laws!
What is an association study?
Lots of people affected by a condition, plus then lots of people as similar to those who have the condition but do not have the condition! (sex, race socioeconomic health etc same)
Association studies track down what type of alleles?
Those that are common but show low/modest effect and only contribute a little
Rare alleles tend to cause what type of inheritance|?
Mendelian
What does SNP stand for?
Single nucleotide polymorphisms
What is linkage disequilibrium?
Like hitch-hiking areas around a specific SNP have been carried through generations see association with snps near by things that have caused it due to the areas around the SNPS that do cause it being the same
What kind of significance is needed to accept an SNP as causing an increased susceptibility?
A very high significant (not that millions of snps are being tested)
Early onset form of alzheimers is known to be genetically heterogeneous, what does this mean?
Different genes in different families but with the same end outcome and features
APOE mutations can cause what condition to appear earlier?
Alzheimers disease
Which varient of APOE is increasing suceptibility and which is protective?
E2/E3 is protective and E4/E4 increases susceptibility
Give examples of multifactorial disease? (4)
Schizophrenia, ARMD, DMII, Alzheimers
