Multifactorial disorders Flashcards
In multifactorial diseases, the bell curve of phenotype distribution in a population is called what?
liability distribution
T/F. In multifactorial disorders the recurrence risk is higher then the occurrence risk.
True
Explain why pyloric stenosis is considered a multifactorial disorder.
More common in male births: 1/100 vs 1/1000 females.
If a girl is born with this disease it means the male is more likely to get it
What is the equation for heritability?
H2 = (Concordance MZ - Concordance DZ) * 2
A heritability of 1 means what? of 0?
1= most likely genetic 0= most likely not genetic
Why are adoption studies useful?
helps determine if a disease is environmental or genetic
What is conducted to reveal which chromosomal regions are shared between affected sibling?
DNA sequence analysis
What describes how many new cases are recorded in a given time, divided by the size of the population?
incidence
What describes the proportion of the population that is affected by the disease at any given time?
prevalence
What is the equation for relative risk ratio?
Lamba2 = prevalence of affected family member/prevalence of general population
What is relative risk ratio used for?
to describe how likely you are to get a disease if your family has the disease
What is relative risk used for?
determining how likely you are to get the disease if you are a carrier by comparing to people that have the disease
What type of penetrance do multifactorial disorders show?
incomplete penetrance
HLA haplotypes are transmitted as a unit and have codominant expression. True or False?
True
HLA-B haplocytes associtaed with risk for?
HLA-C haplo?
spondyloarthropathy
psoriatic arthritis
