Mucosal Changes Flashcards

1
Q

What is the cancer referral pathway and when should this be used?

A

Anything that the dentist thinks might be cancer/ dysplasia
2 week pathway for malignancies

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2
Q

When should a lesion be referred to oral medicine?

A

If symptomatic and hasn’t responded to standard treatment or any benign lesion that a pt cant be persuaded isn’t cancer.

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3
Q

What are the layers of the oral mucosa?

A

Stratified squamous epithelium with underlying lamina propia (contains blood vessels)

Stratum corneum
Granulosum
Spinosum
Basal

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4
Q

What are the reactive changes of the oral epithelium?

A

Keratosis (non-keratinised sites)
Acanthosis (hyperplasia of stratum spinosum) - thickening
Elongated rete ridges (hyperplasia of basal cells)

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5
Q

What are mucosal changes?

A

Atrophy - reduction in viable layers
Erosion - partial thickness loss
Ulceration - fibrin on surface
Oedema - Intracellular/ intercellular (spongiosis)
Blister - vesicle or bulla

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6
Q

What is geographic tongue?

A

Disordered maturation and replacement of epithelial surface of tongue (benign condition)

Random areas are rep[laced at one time randomly, in geographic tongue, whole areas of epithelium are replaced at once, causing thinning and red appearance.

Can be sensitive at first (especially to spicy/ citrus foods)

May be due to haemantinics deficiency, parafunctional trauma, dysaesthesia

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7
Q

What is black hairy tongue?

A

Elongation of surface papillae which become stained
Can be from soft/ liquid diet

Remove elongated papilla with tongue scraper

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8
Q

What is fissured tongue

A

Has unknown cause
Can be due to dry mouth
Can be painful if becomes deep (food gets stuck, hard to clean)

May be associated with candida/ lichen planus

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9
Q

What is glossitis?

A

Atrophy, smooth, red appearance of the tongue

Investigate - haemantinics, fungal cultures

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10
Q

When should swellings in the mouth be referred?

A

If symptomatic
Abnormal overlying and surrounding mucosa
Increase in size
Rubber consistency
Trauma from teeth

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11
Q

What type of intra oral swellings should not be referred?

A

Tori (bony swelling in lingual of mandible/ midline palate)
Small polyps
Mucoceles

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12
Q

What is a fibrous polyp?

A

Caused by minor trauma or irritation
Benign tumour

Can get ‘leaf fibroma’ from polyp being squashed under denture

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13
Q

What is a pyogenic granuloma?

A

Granulation tissue (mixed inflammatory infiltrate on fibro vascular background)

Can occur on any mucosal site, response to trauma

No epithelial surface

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14
Q

What are reasons for white lesions in the mouth?

A

Hereditary
Smoking/ frictional keratosis
Lichen planus
Candida leukoplakia
Carcinoma

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15
Q

Why are white lesions white?

A

Increased thickness of epithelium, increases the opacity (making it less pink, less visibility of blood)

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16
Q

what is leukoplakia

A

A white patch which cannot be rubbed off or attributed to any other cause
<1% malignancy risk

17
Q

What is smokers keratosis?

A

Trauma from the thermal gases resulting in white patches (on hard palate)
Melanin over production
Low malignant risk of the lesion, but higher cancer risk overall

18
Q

What is white sponge naevus?

A

Hereditary white patches
Starts in childhood, FH
No traumatic

19
Q

Why are red lesions red?

A

Inflammation
Dysplasia
(Reduced thickness of epithelium)

20
Q

What is erythroplakia?

A

Unexplained red change
Cannot be attributed to any other cause

More of a malignant concern than leukoplakia

21
Q

What causes blue lesions?

A

Fluid in connective tissue
Dark blue - slow moving blood
Light blue - clear fluid eg saliva (mucocele), lymph

22
Q

Name 3 local and 3 general causes of pigmentation?

A

Local - malignant melanoma, melanocytic neavus, amalgam tattoo, haemangioma
General - racial pigmentation, addisons disease, smoking

23
Q

How does addisons disease affect the oral mucosa?

A

Hyperpigmentation resulting in brown appearance of gingiva/ mucosa/ tongue/ lips

24
Q

What are the two types of haemangioma?

A

Capillary and cavernous

25
Q

What is a capillary haemangioma?

A

Haemangioma filled with thin walled capillaries

26
Q

What is a cavernous haemangioma?

A

Encapsulated haemangioma with dilated vascular spaces.

27
Q

What are the 6 types of candida?

A

Pseudomembranous
Denture induced
Erythematous
Hyper plastic
Angular cheilitis
Median rhomboid glossitis

28
Q

What are the virulence factors of S mutans?

A

ASAP
Adhesins
Sugar modifier enzyme
Acidic tolerance and adaption
Polysaccharide binding protein

29
Q

What are the virulence factors of Candida albicans?

A

GAMES
Germ tube formation
Adhesins
Metabolites (acidic)
Extra cellular enzymes
Switching mechanisms

30
Q

What are the tests for candida?

A

Swab, biopsy, oral rinse

31
Q

What are contraindications for -Azoles

A

Warfarin
Statins

32
Q

What is median rhomboid glossitis?

A

For sum of the tongue from anterior to sulcus terminalis
Candida hyphae infiltration and elongated rete ridges
Hyper plastic rete ridges

33
Q

What is the histology stain used for candida?

A

PAS
Periodic acidic Schiff stain