mucor Flashcards
MC mucormycosis species in west
Rhizopus oryzae
Mucormycosis species can encounter
Rhizopus oryzae (MC)
Rhizomucor pusillus
Lichtheimia corymbifera (formerly Absidia corymbifera)
Apophysomyces elegans
Cuninghamella
Mucor (despite its name it rarely causes the disease)
At risk for mucormycosis
iron overloaded w/ ESRD neutropenic defects in phagocytic function glucocorticoid tx DKA - risk of rhinocerebral mucormycosis
3 likely mechanisms of mucormycosis
- hyperglycalation of iron sequestering proteins
- ….upregulation of mammalian receptors
- induction of poor phagocytic function
MC mucormycosis ds
rhinocerebral.
diabeteics
transplant pts with corticosteroids
What is suspicious for mucormycosis vs aspergillosis on chest x ray
> 10 nodules
pleural effusion
or concomittant sinusitis
Voriconazole in relation to mucormycosis
it prob antagonizes
BMT wiht rhinovirus and eye swelling
omg
no chemosis, pain or numbness
pos for suffusion
Types of mucormycosis inx
rhinocerebral MC
pulmonary
cutanteous (puncture or hematogenous)
GI
Mucor lab
should be minced
should be at RT and 35 since wide temp variablility
Klebsiella species that can present similar to mucormycosis
Klebsiella rhinoscleromatis
Mucormycosis tx
careful w/ blood transfusions bc can liberate free iron careful w/ corticosteroids 1. prompt ID 2. debridement 3. correct abx 4. reverse RF if possible
Tx abx
amphotericin
posa
(not vori)
AmB deoxycholate
only licensed for mucor
cheap
50 years data
disadvantages
highy toxic
poor cns penetration
LAmB
less nephrogenic than AmB deoxycholate
better CNS penetrati
dis
expensive
