Mucoactive Agents

Question 1

Mucoactive Agents

Generic Names (4)
Trade Names (2)

Answer 1

1. N-Acetylcysteine (Trade Name: NAC, Mucomyst)
2. Dornase Alfa (Trade Name: Pulmozyme)
3. Aqueous Water Saline
4. Hyperosmolar Saline 3% and 7%

Question 2

Mucoactive Agents
N-Acetylcysteine (NAC, Mucomyst)

Use
Mode of Action
Hazards (4)

Answer 2

1. Use: None
2. MOA: Breaks down disulfide bonds
3. Hazards: Bronchospasms, Rhinorrhea, Stomatitis, Nausea

Question 3

Mucoactive Agents
Dornase Alfa (Pulmozyme)

Use
Mode of Action
Hazards (6)

Answer 3

1. Use: Used in CF only “orphan drug”
2. MOA: Reduces the viscosity and adhesivity of DNA polymers in CF
3. Hazards: Pharyngitis, Laryngitis, Conjunctivitis, Rash, Chest Pains, Voice Alteration

Question 4

Mucoactive Agents
Aqueous Water Saline

Use
Mode of Action
Hazards (2)

Answer 4

1. Use: Sputum Induction
2. MOA: Irritant to induce cough. Improves mucociliary transport and lung function. Hydrates airway surface fluids
3. Hazards: Bronchospasms and Cough

Question 5

Mucoactive Agents
Hyperosmolar Saline 3% and 7%

Use
Mode of Action
Hazards (2)

Answer 5

1. Use: Airway Clearance for therapy of CF. 3% Infinitive Bronchiolitis
2. MOA: Irritant to induce cough. Improves mucociliary transport and lung function
3. Hazards: Bronchospasms and Cough